Synonyms: Apoptosis regulator BAK,BAK,BAK like,Bak NT,BAK,Bak1,Bcl 2 homologous antagonist/killer,Bcl 2 like 7 protein,Bcl-2 homologous antagonist/killer,Bcl-2-like protein 7,BCL2 antagonist/killer 1,Bcl2 like 7 Protein,Bcl2-L-7,BCL2L7,CDN1,Cell death inhibitor 1,MGC117255,MGC3887,NBak,Pro apoptotic protein BAK
Background: The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress.