DVL1 Antikörper (AA 442-470)

Produktnummer ABIN656260

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch DVL1 in WB, IF und IHC (p). Er zeigt eine Reaktivität gegenüber Human und Maus und wurde in 1 Publikation erwähnt.

Kurzübersicht für DVL1 Antikörper (AA 442-470) (ABIN656260)

Target: DVL1 (Dishevelled Segment Polarity Protein 1 (DVL1))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DVL1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: RB31716

Produktdetails anti-DVL1 Antikörper

Bindungsspezifität: AA 442-470

Homologie: Rat

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This DVL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 442-470 amino acids from the Central region of human DVL1.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: IF: 1:10~50. IF: 1:25. WB: 1:1000. WB: 1:2000. WB: 1:1000. IHC-P: 1:10~50. IHC-P: 1:25

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-DVL1 Antikörper (ABIN656260)

Bunn, Daniel, Rösken, ONeill, Cameron-Christie, Morgan, Brunner, Lai, Kunst, Markie, Robertson: "Mutations in DVL1 cause an osteosclerotic form of Robinow syndrome." in: American journal of human genetics, Vol. 96, Issue 4, pp. 623-30, (2015) (PubMed).

Details zu DVL1

Target: DVL1 (Dishevelled Segment Polarity Protein 1 (DVL1))

Andere Bezeichnung: DVL1

Hintergrund: DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 is a candidate gene for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development.

Molekulargewicht: 75187

Gen-ID: 1855

NCBI Accession: NP_004412

UniProt: O14640

Pathways: WNT Signalweg, Synaptic Membrane, Skeletal Muscle Fiber Development