Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

GNAT3 Antikörper (AA 78-105)

This anti-GNAT3 antibody (ABIN654441) is a Rabbit Polyclonal antibody detecting GNAT3 in WB, FACS, IHC (p). Suitable for Human.
Produktnummer ABIN654441

Quick Overview for GNAT3 Antikörper (AA 78-105) (ABIN654441)

Target

Alle GNAT3 Antikörper anzeigen
GNAT3 (Guanine Nucleotide Binding Protein, alpha Transducing 3 (GNAT3))

Reaktivität

  • 24
  • 8
  • 8
Human

Wirt

  • 23
  • 1
Kaninchen

Klonalität

  • 24
Polyklonal

Konjugat

  • 7
  • 3
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser GNAT3 Antikörper ist unkonjugiert

Applikation

  • 14
  • 12
  • 12
  • 10
  • 2
  • 1
  • 1
Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon

RB24621
  • Bindungsspezifität

    • 6
    • 4
    • 4
    • 4
    • 3
    • 1
    • 1
    AA 78-105

    Aufreinigung

    This antibody is purified through a protein A column, followed by peptide affinity purification.

    Immunogen

    This GNAT3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 78-105 amino acids from the Central region of human GNAT3.

    Isotyp

    Ig Fraction
  • Applikationshinweise

    WB: 1:1000. IHC-P: 1:50~100. FC: 1:10~50

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

    Haltbarkeit

    6 months
  • Target

    GNAT3 (Guanine Nucleotide Binding Protein, alpha Transducing 3 (GNAT3))

    Andere Bezeichnung

    GNAT3

    Hintergrund

    Guanine nucleotide-binding protein (G protein) alpha subunit playing a prominent role in bitter and sweet taste transduction as well as in umami (monosodium glutamate, monopotassium glutamate, and inosine monophosphate) taste transduction. Transduction by this alpha subunit involves coupling of specific cell-surface receptors with a cGMP-phosphodiesterase, Activation of phosphodiesterase lowers intracellular levels of cAMP and cGMP which may open a cyclic nucleotide-suppressible cation channel leading to influx of calcium, ultimately leading to release of neurotransmitter. Indeed, denatonium and strychnine induce transient reduction in cAMP and cGMP in taste tissue, whereas this decrease is inhibited by GNAT3 antibody. Gustducin heterotrimer transduces response to bitter and sweet compounds via regulation of phosphodiesterase for alpha subunit, as well as via activation of phospholipase C for beta and gamma subunits, with ultimate increase inositol trisphosphate and increase of intracellular Calcium. GNAT3 can functionally couple to taste receptors to transmit intracellular signal: receptor heterodimer TAS1R2/TAS1R3 senses sweetness and TAS1R1/TAS1R3 transduces umami taste, whereas the T2R family GPCRs act as bitter sensors. Functions also as lumenal sugar sensors in the gut to control the expression of the Na+-glucose transporter SGLT1 in response to dietaty sugar, as well as the secretion of Glucagon-like peptide-1, GLP-1 and glucose-dependent insulinotropic polypeptide, GIP. Thus, may modulate the gut capacity to absorb sugars, with implications in malabsorption syndromes and diet-related disorders including diabetes and obesity.

    Molekulargewicht

    40357

    Gen-ID

    346562

    NCBI Accession

    NP_001095856

    UniProt

    A8MTJ3

    Pathways

    Peptide Hormone Metabolism, G-protein mediated Events, Phototransduction
Sie sind hier:
Chat with us!