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CXCR3 Antikörper (AA 140-167)

Dieses Anti-CXCR3-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von CXCR3 in FACS, WB und IHC (p). Geeignet für Human.
Produktnummer ABIN654129

Kurzübersicht für CXCR3 Antikörper (AA 140-167) (ABIN654129)

Target

Alle CXCR3 Antikörper anzeigen
CXCR3 (Chemokine (C-X-C Motif) Receptor 3 (CXCR3))

Reaktivität

  • 110
  • 54
  • 17
  • 1
Human

Wirt

  • 86
  • 36
  • 12
  • 7
  • 1
  • 1
Kaninchen

Klonalität

  • 75
  • 68
Polyklonal

Konjugat

  • 57
  • 12
  • 11
  • 6
  • 5
  • 5
  • 4
  • 4
  • 3
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser CXCR3 Antikörper ist unkonjugiert

Applikation

  • 74
  • 72
  • 42
  • 38
  • 17
  • 16
  • 14
  • 14
  • 13
  • 12
  • 6
  • 4
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Flow Cytometry (FACS), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon

RB23384
  • Bindungsspezifität

    • 16
    • 7
    • 6
    • 6
    • 6
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 140-167

    Aufreinigung

    This antibody is purified through a protein A column, followed by peptide affinity purification.

    Immunogen

    This CXCR3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 140-167 amino acids of human CXCR3.

    Isotyp

    IgG
  • Applikationshinweise

    WB: 1:1000. IHC-P: 1:50~100. FC: 1:10~50

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

    Haltbarkeit

    6 months
  • Target

    CXCR3 (Chemokine (C-X-C Motif) Receptor 3 (CXCR3))

    Andere Bezeichnung

    CXCR3

    Hintergrund

    This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed IP10 (interferon-g-inducible 10 kDa protein), Mig (monokine induced by interferon-g) and I-TAC (interferon-inducible T cell a-chemoattractant). IP10, Mig and I-TAC belong to the structural subfamily of CXC chemokines, in which a single amino acid residue separates the first two of four highly conserved Cys residues. Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Inhibition by Bordetella pertussis toxin suggests that heterotrimeric G protein of the Gi-subclass couple to this protein. Signal transduction has not been further analyzed but may include the same enzymes that were identified in the signaling cascade induced by other chemokine receptors. As a consequence of chemokine-induced cellular desensitization (phosphorylation-dependent receptor internalization), cellular responses are typically rapid and short in duration. Cellular responsiveness is restored after dephosphorylation of intracellular receptors and subsequent recycling to the cell surface. This gene is prominently expressed in in vitro cultured effector/memory T cells, and in T cells present in many types of inflamed tissues. In addition, IP10, Mig and I-TAC are commonly produced by local cells in inflammatory lesion, suggesting that this gene and its chemokines participate in the recruitment of inflammatory cells. Therefore, this protein is a target for the development of small molecular weight antagonists, which may be used in the treatment of diverse inflammatory diseases. Multiple transcript variants encoding different isoforms have been found for this gene.

    Molekulargewicht

    40660

    Gen-ID

    2833

    NCBI Accession

    NP_001136269, NP_001495

    UniProt

    P49682
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