Angiopoietin 2 Antikörper (C-Term)

Produktnummer ABIN654062

Der Kaninchen Polyklonal Anti-Angiopoietin 2-Antikörper wurde für WB, IHC (p) und FACS validiert. Er ist geeignet, Angiopoietin 2 in Proben von Human und Maus zu detektieren. Es sind 2+ Publikationen verfügbar.

Kurzübersicht für Angiopoietin 2 Antikörper (C-Term) (ABIN654062)

Target: Angiopoietin 2 (ANGPT2)

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Angiopoietin 2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Klon: RB17789

Produktdetails anti-Angiopoietin 2 Antikörper

Bindungsspezifität: AA 404-432, C-Term

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This ANGPT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 404-432 amino acids from the C-terminal region of human ANGPT2.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. WB: 1:2000. IHC-P: 1:50~100. FC: 1:25

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-Angiopoietin 2 Antikörper (ABIN654062)

Alamo, Gallardo, Di Nicolantonio, Pavón, Casanova, Trias, Mangues, Lopez-Pousa, Villaverde, Vázquez, Bardelli, Céspedes, Mangues: "Higher metastatic efficiency of KRas G12V than KRas G13D in a colorectal cancer model." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 29, Issue 2, pp. 464-76, (2015) (PubMed).

Alamo, Gallardo, Pavón, Casanova, Trias, Mangues, Vázquez, Villaverde, Mangues, Céspedes: "Subcutaneous preconditioning increases invasion and metastatic dissemination in mouse colorectal cancer models." in: Disease models & mechanisms, Vol. 7, Issue 3, pp. 387-96, (2014) (PubMed).

Details zu Angiopoietin 2

Target: Angiopoietin 2 (ANGPT2)

Andere Bezeichnung: ANGPT2

Hintergrund: The protein encoded by this gene is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2, TEK). The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. Three transcript variants encoding three different isoforms have been found for this gene.

Molekulargewicht: 56919

Gen-ID: 285

NCBI Accession: NP_001112359, NP_001112360, NP_001138

UniProt: O15123

Pathways: RTK Signalweg