DERL1 Antikörper (C-Term)

Produktnummer ABIN652693

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch DERL1 in WB, IHC (p) und FACS. Er zeigt eine Reaktivität gegenüber Human und Maus.

Kurzübersicht für DERL1 Antikörper (C-Term) (ABIN652693)

Target: DERL1 (Der1-Like Domain Family, Member 1 (DERL1))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DERL1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Klon: RB22770

Produktdetails anti-DERL1 Antikörper

Bindungsspezifität: AA 224-251, C-Term

Homologie: B

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This DERL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 224-251 amino acids from the C-terminal region of human DERL1.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:16000. WB: 1:1000. IHC-P: 1:50~100. FC: 1:10~50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Details zu DERL1

Target: DERL1 (Der1-Like Domain Family, Member 1 (DERL1))

Andere Bezeichnung: DERL1

Hintergrund: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. DERL1 may act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome. It may mediate the interaction between VCP and the degradation substrate. In case of infection by cytomegaloviruses, it plays a central role in the export from the ER and subsequent degradation of MHC class I heavy chains via its interaction with US11 viral protein, which recognizes and associates with MHC class I heavy chains. Also participates in the degradation process of misfolded cytomegalovirus US2 protein.

Molekulargewicht: 28801

Gen-ID: 79139

NCBI Accession: NP_001128143, NP_077271

UniProt: Q9BUN8

Pathways: ER-Nucleus Signaling