ERBB3 Antikörper

Produktnummer ABIN645836

Der Ziege not_set anti-ERBB3 Antikörper wird verwendet zum Nachweis von ERBB3 in Proben von Maus und Ratte.

Kurzübersicht für ERBB3 Antikörper (ABIN645836)

Target: ERBB3 (Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3))

Reaktivität: Maus, Ratte

Wirt: Ziege

Konjugat: Dieser ERBB3 Antikörper ist unkonjugiert

Applikation: Bitte anfragen

Produktdetails anti-ERBB3 Antikörper

Spezifität: The ErbB3 goat antibody detects protein derived from human, Jurkat cell lysate at various concentrations.

Kreuzreaktivität: Maus, Ratte (Rattus)

Produktmerkmale: Goat Anti-ERBB3 / HER3

Immunogen: Peptide with sequence -HSRLFPKANAQRT, from the C-terminus of the protein sequence according to NP_001973.2. was used as immunogen.

Isotyp: IgG

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: Supplied as 100 µg of purified antibody. 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Please avoid freeze-thaw cycles.

Lagerung: -20 °C

Details zu ERBB3

Target: ERBB3 (Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3))

Andere Bezeichnung: ERBB3 / HER3

Hintergrund: The EGF receptor family comprises several related receptor tyrosine kinases that are frequently overexpressed in a variety of carcinomas. Members of this receptor family include EGFR (HER1), Neu (ErbB-2, HER2), ErbB-3 (HER3) and ErbB-4 (HER4), which form either homodimers or heterodimers upon ligand binding. Full length ErbB-3 is detected at 180 kDa by SDS-PAGE and is overexpressed in human mammary tumors. The ErbB-3 gene also produces several alternative variants, including a secreted form of 85 kDa which negatively regulates heregulin-stimulated ErbB activation. ErbB-3 heterodimerizes with Neu and binds heregulin in order to activate phosphoinositide (PI) 3-kinase. The recruitment and activation of PI 3-kinase occurs via its interaction with phosphorylated YXXM motifs in the carboxy terminus of ErbB-3.

NCBI Accession: NP_001973

Pathways: RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung