Dieses Anti-EBV LMP2A-Antikörper ist ein Ratte -Antikörper zur Detektion von EBV LMP2A in IHC (p) und WB. Geeignet für Epstein-Barr Virus (EBV).
Produktnummer ABIN644979
Kurzübersicht für EBV LMP2A Antikörper (ABIN644979)
Target
EBV LMP2A
(Epstein-Barr Virus Latent Membrane Protein 2A (EBV LMP2A))
Reaktivität
Epstein-Barr Virus (EBV)
Wirt
Ratte
Konjugat
Dieser EBV LMP2A Antikörper ist unkonjugiert
Applikation
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Spezifität
DS-MB-03627 recognizes latent membrane protein 2A (LMP2A) of Epstein-Barr virus (EBV). EBV is a human herpes virus, which is associated with conditions such as Hodgkin's disease and Burkitt's Lymphoma and is the causative agent in mononucleosis in adolescents. EBV latently infects B lymphocytes. Infected B cells express EBV nuclear antigens and latent proteins LMP1, LMP2A and LMP2B. LMP2A forms aggregates in the plasma membranes of B lymphocytes, where it functions as a negative regulator of the Src and Syk protein tyrosine kinases. Studies show that LMP2A blocks B-cell receptor (BCR) signal transduction in EBV immortalized B cells in vitro and may play an important role in maintaining a latent EBV infection within the peripheral blood B cells of infected individuals. DS-MB-03627 specifically recognizes LMP2A and does not cross react with LMP2B.