Oncostatin M Antikörper

Produktnummer ABIN636696

Produktdetails anti-Oncostatin M Antikörper

Target: Oncostatin M (OSM)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Oncostatin M Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Blocking Antibody (Inhibition)

Aufreinigung: Purified

Immunogen: Oncostatin M antibody was raised in rabbit using highly pure recombinant human oncostatin M as the immunogen.

Anwendungsinformationen

Applikationshinweise: ELISA: 0.5-2 µg/mL, Inhibition: 0.1-0.175 µg/mL, WB: 0.1-0.2 µg/mL
Optimal conditions should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Konzentration: Lot specific

Buffer: Lyophilized from PBS, pH 7.2.

Handhabung: Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at -20 °C until reconstitution. Following reconstitution product may be stored at 4 °C in the short term. For long term storage aliquot and freeze at -20 °C.

Details zu Oncostatin M

Target: Oncostatin M (OSM)

Andere Bezeichnung: Oncostatin M (OSM Produkte)

Synonyme: OSM antikoerper, OncoM antikoerper, oncostatin M antikoerper, OSM antikoerper, Osm antikoerper

Hintergrund: Oncostatin M (OSM) is a growth and differentiation factor that participates in the regulation of neurogenesis, osteogenesis and hematopoiesis. Produced by activate T cells, monocytes and Kaposi’s sarcoma cells, OSH can exert both stimulatory and inhibitory effects on cell proliferation. It stimulates the proliferation of fibroblasts, smooth muscle cells and Kaposi’s sarcoma cells, but, inhibits the growth of some normal and tumor cell lines. It also promotes cytokine release (e.g. IL6, GM-CSF and G-CSF) from endothelial cells, and enhances the expression of low-density lipoprotein receptor in hepatoma cells. OSM share several structural and functional characteristics with LIF, IL6, and CNTF. Human OSM is active on Mouse cells.

Molekulargewicht: 23.9 kDa (predicted detection band MW)

Pathways: JAK-STAT Signalweg, Negative Regulation of Hormone Secretion