ube3a Antikörper (N-Term)

Produktnummer ABIN633810

Dieses Anti-ube3a-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von ube3a in WB. Geeignet für Human.

Kurzübersicht für ube3a Antikörper (N-Term) (ABIN633810)

Target: ube3a (Ubiquitin Protein Ligase E3A (ube3a))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ube3a Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-ube3a Antikörper

Bindungsspezifität: N-Term

Spezifität: UBE3 A antibody was raised against the N terminal Of Ube3

Aufreinigung: Affinity purified

Immunogen: UBE3 A antibody was raised using the N terminal Of Ube3 corresponding to a region with amino acids SLQAKDEDKDEDEKEKAACSAAAMEEDSEASSSRIGDSSQGDNNLQKLGP

Anwendungsinformationen

Applikationshinweise: WB: 1 µg/mL
Optimal conditions should be determined by the investigator.

Kommentare:

UBE3A Blocking Peptide, (ABIN5616878), is also available for use as a blocking control in assays to test for specificity of this UBE3A antibody

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Lyophilized powder. Add distilled water for a 1 mg/mL concentration of UBE0 antibody in PBS

Konzentration: Lot specific

Buffer: PBS

Handhabung: Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2-8 °C for short periods. For longer periods of storage, store at -20 °C.

Details zu ube3a

Target: ube3a (Ubiquitin Protein Ligase E3A (ube3a))

Andere Bezeichnung: UBE3A

Hintergrund: UBE3A is an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53.

Molekulargewicht: 101 kDa (MW of target protein)

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway