Prohibitin 2 Antikörper (C-Term)

Produktnummer ABIN630990

Dieses Anti-Prohibitin 2-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Prohibitin 2 in WB. Geeignet für Human, Maus und Ratte.

Kurzübersicht für Prohibitin 2 Antikörper (C-Term) (ABIN630990)

Target: Prohibitin 2 (PHB2)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Prohibitin 2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Prohibitin 2 Antikörper

Bindungsspezifität: C-Term

Spezifität: Prohibitin 2 antibody was raised against the C terminal of PHB2

Aufreinigung: Affinity purified

Immunogen: Prohibitin 2 antibody was raised using the C terminal of PHB2 corresponding to a region with amino acids KLRKIRAAQNISKTIATSQNRIYLTADNLVLNLQDESFTRGSDSLIKGKK

Anwendungsinformationen

Applikationshinweise: WB: 0.5 µg/mL
Optimal conditions should be determined by the investigator.

Kommentare:

Prohibitin 2 Blocking Peptide, (ABIN939919), is also available for use as a blocking control in assays to test for specificity of this Prohibitin 2 antibody

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Lyophilized powder. Add distilled water for a 1 mg/mL concentration of PHB2 antibody in PBS

Konzentration: Lot specific

Buffer: PBS

Handhabung: Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2-8 °C for short periods. For longer periods of storage, store at -20 °C.

Details zu Prohibitin 2

Target: Prohibitin 2 (PHB2)

Andere Bezeichnung: Prohibitin 2

Hintergrund: PHB2 acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). It functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. PHB2 competes with NCOA1 for modulation of ER transcriptional activity. It probably involved in regulating mitochondrial respiration activity and in aging.

Molekulargewicht: 33 kDa (MW of target protein)

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling