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MCM4 Antikörper (C-Term)

This anti-MCM4 antibody (ABIN630174) is a Rabbit Polyclonal antibody detecting MCM4 in WB. Suitable for Human, Mouse, Rat, Dog.
Produktnummer ABIN630174

Kurzübersicht für MCM4 Antikörper (C-Term) (ABIN630174)

Target

Alle MCM4 Antikörper anzeigen
MCM4 (Minichromosome Maintenance Deficient 4 (MCM4))

Reaktivität

  • 90
  • 44
  • 23
  • 10
  • 10
  • 9
  • 9
  • 8
  • 5
  • 5
  • 4
  • 3
  • 3
  • 3
Human, Maus, Ratte, Hund

Wirt

  • 84
  • 4
  • 3
Kaninchen

Klonalität

  • 88
  • 3
Polyklonal

Konjugat

  • 54
  • 5
  • 4
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser MCM4 Antikörper ist unkonjugiert

Applikation

  • 69
  • 33
  • 32
  • 13
  • 13
  • 13
  • 11
  • 4
  • 3
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
Western Blotting (WB)
  • Bindungsspezifität

    • 15
    • 8
    • 7
    • 6
    • 6
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term

    Spezifität

    MCM4 antibody was raised against the C terminal of MCM4

    Aufreinigung

    Purified

    Immunogen

    MCM4 antibody was raised using the C terminal of MCM4 corresponding to a region with amino acids KEELAEALKKLILSKGKTPALKYQQLFEDIRGQSDIAITKDMFEEALRAL
  • Applikationshinweise

    WB: 5 µg/mL
    Optimal conditions should be determined by the investigator.

    Kommentare

    MCM4 Blocking Peptide, catalog no. 33R-4325, is also available for use as a blocking control in assays to test for specificity of this MCM4 antibody

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Lyophilized powder. Add distilled water for a 1 mg/mL concentration of MCM4 antibody in PBS

    Konzentration

    Lot specific

    Buffer

    PBS

    Handhabung

    Avoid repeated freeze/thaw cycles.
    Dilute only prior to immediate use.

    Lagerung

    4 °C/-20 °C

    Informationen zur Lagerung

    Store at 2-8 °C for short periods. For longer periods of storage, store at -20 °C.
  • Target

    MCM4 (Minichromosome Maintenance Deficient 4 (MCM4))

    Andere Bezeichnung

    MCM4

    Hintergrund

    The protein encoded by MCM4 is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRkDaC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported.

    Molekulargewicht

    95 kDa (MW of target protein)

    Pathways

    DNA Reparatur, Mitotic G1-G1/S Phases, DNA Replication, Chromatin Binding, Synthesis of DNA
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