MCM4 Antikörper (C-Term)
Kurzübersicht für MCM4 Antikörper (C-Term) (ABIN630174)
Target
Alle MCM4 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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                                            Bindungsspezifität
- C-Term
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                                            Spezifität
- MCM4 antibody was raised against the C terminal of MCM4
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                                            Aufreinigung
- Purified
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                                            Immunogen
- MCM4 antibody was raised using the C terminal of MCM4 corresponding to a region with amino acids KEELAEALKKLILSKGKTPALKYQQLFEDIRGQSDIAITKDMFEEALRAL
 
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                                            Applikationshinweise
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                        WB: 5 µg/mL
 Optimal conditions should be determined by the investigator.
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                                            Kommentare
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                        MCM4 Blocking Peptide, (ABIN939711), is also available for use as a blocking control in assays to test for specificity of this MCM4 antibody 
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                                            Beschränkungen
- Nur für Forschungszwecke einsetzbar
 
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                                            Format
- Lyophilized
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                                            Rekonstitution
- Lyophilized powder. Add distilled water for a 1 mg/mL concentration of MCM4 antibody in PBS
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                                            Konzentration
- Lot specific
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                                            Buffer
- PBS
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                                            Handhabung
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                        Avoid repeated freeze/thaw cycles. 
 Dilute only prior to immediate use.
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                                            Lagerung
- 4 °C/-20 °C
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                                            Informationen zur Lagerung
- Store at 2-8 °C for short periods. For longer periods of storage, store at -20 °C.
 
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    - MCM4 (Minichromosome Maintenance Deficient 4 (MCM4))
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                                            Andere Bezeichnung
- MCM4
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                                            Hintergrund
- The protein encoded by MCM4 is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRkDaC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported.
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                                            Molekulargewicht
- 95 kDa (MW of target protein)
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                                            Pathways
- DNA Reparatur, Mitotic G1-G1/S Phases, DNA Replication, Chromatin Binding, Synthesis of DNA
 Target
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