KNG1 Antikörper (Biotin)
-
- Target Alle KNG1 Antikörper anzeigen
- KNG1 (Kininogen 1 (KNG1))
-
Reaktivität
- Human
-
Wirt
- Kaninchen
-
Klonalität
- Polyklonal
-
Konjugat
- Dieser KNG1 Antikörper ist konjugiert mit Biotin
-
Applikation
- Western Blotting (WB), ELISA
- Verwendungszweck
- Rabbit anti-Human Bradykinin [+Biotin] Antibody,
- Immunogen
- This antibody was produced from antiserum of rabbits immunized with a polypeptide immunogen. The IgG fraction was purified by Protein G/A affinity chromatography.
- Isotyp
- IgG
- Top Product
- Discover our top product KNG1 Primärantikörper
-
-
- Applikationshinweise
- ELISA (recommended work dilution= 1:16,000), Western Blotting (recommended work dilution= 1:1,000-5,002),
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Rekonstitution
- Product is supplied as a powder obtained from lyophilization of purified antibody in PBS without preservatives. Reconstitute the antibody with sterile 1 x PBS to a final concentration of 1 mg/mL.
- Lagerung
- 4 °C,-20 °C,-80 °C
- Informationen zur Lagerung
- -20°C
-
- Target
- KNG1 (Kininogen 1 (KNG1))
- Andere Bezeichnung
- Kininogen-1 , Kininogen-1 light chain, Low molecular weight growth-promoting factor] (KNG1 Produkte)
- Synonyme
- BDK antikoerper, BK antikoerper, KNG antikoerper, Kng antikoerper, KNG2 antikoerper, fb64g01 antikoerper, wu:fb64g01 antikoerper, zgc:103569 antikoerper, kininogen antikoerper, bdk antikoerper, kng antikoerper, KNG1 antikoerper, IHRP antikoerper, KINKG antikoerper, KINKH antikoerper, Kng1 antikoerper, Kngk antikoerper, kininogen 1 antikoerper, kininogen 1 L homeolog antikoerper, inter-alpha-trypsin inhibitor heavy chain family member 4 antikoerper, kininogen 2-like 1 antikoerper, KNG1 antikoerper, Kng1 antikoerper, kng1 antikoerper, kng1.L antikoerper, ITIH4 antikoerper, Kng2l1 antikoerper
- Hintergrund
-
Target Description: Bradykinin is a potent endothelium-dependent vasodilator, leading to a drop in blood pressure. It also causes contraction of non-vascular smooth muscle in the bronchus and gut, increases vascular permeability and is also involved in the mechanism of pain.Bradykinin also causes natriuresis, contributing to the drop in blood pressure.Bradykinin raises internal calcium levels in neocortical astrocytes causing them to release glutamate.Bradykinin is also thought to be the cause of the dry cough in some patients on angiotensin-converting enzyme (ACE) inhibitor drugs. It is thought that bradykinin is converted to inactive metabolites by ACE, therefore inhibition of this enzyme leads to increased levels of bradykinin, which causes a dry cough via bronchoconstriction. This refractory cough is a common cause for stopping ACE inhibitor therapy, in which case angiotensin II receptor antagonists (ARBs) are the next line of treatment.Overactivation of bradykinin is thought to play a role in a rare disease called hereditary angioedema, formerly known as hereditary angio-neurotic edema.
Gene Symbol: KNG1///BDK///KNG
- Gen-ID
- 3827
- UniProt
- P01042
- Pathways
- ACE Inhibitor Pathway, Glycosaminoglycan Metabolic Process
-