IGHM Antikörper

Produktnummer ABIN6297767

Der Maus Monoklonal Anti-IGHM-Antikörper wurde für IHC validiert. Er ist geeignet, IGHM in Proben von Human zu detektieren.

Kurzübersicht für IGHM Antikörper (ABIN6297767)

Target: IGHM (Immunoglobulin Heavy Constant mu (IGHM))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser IGHM Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Produktdetails anti-IGHM Antikörper

Verwendungszweck: Mouse anti-Human IgM Antibody [IHC only]

Spezifität: Cytoplasm, cell surface and secreted

Aufreinigung: The Mu heavy chain of human Ig was used as the immunogen for the Anti-IgM antibody.

Immunogen: The Mu heavy chain of human Ig was used as the immunogen for the Anti-IgM antibody.

Anwendungsinformationen

Applikationshinweise: Prediluted format : incubate for 30 min at RT (2)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Prediluted in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide, For IHC use only

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Details zu IGHM

Target: IGHM (Immunoglobulin Heavy Constant mu (IGHM))

Andere Bezeichnung: Immunoglobulin heavy constant mu

Hintergrund:

Target Description: Recognizes a protein of 75 kDa, identified as mu heavy chain of human immunoglobulins. It does not cross-react with alpha (IgA), gamma (IgG), epsilon (IgE), or delta (IgD), heavy chains, T-cells, monocytes, granulocytes, or erythrocytes. Monomeric IgM is expressed as a membrane bound antibody on the surface of B cells and as a pentamer when secreted by plasma cells. IgM antibody is prominent in early immune responses to most antigens. Aberrant levels are associated with immune deficiency states, hereditary deficiencies, myeloma, Waldenstrom's macroglobulinemia, chronic infection and hepatocellular disease. This mAb is useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkins lymphomas. The most common feature of these malignancies is the restricted expression of a single heavy chain class. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is clonal and therefore malignant.

Gene Symbol: IGHM

Gen-ID: 3507

UniProt: P01871