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Melanoma gp100 Antikörper

PMEL Reaktivität: Human IF, IHC, FACS, WB Wirt: Maus Monoclonal unconjugated
Produktnummer ABIN6297733
  • Target Alle Melanoma gp100 (PMEL) Antikörper anzeigen
    Melanoma gp100 (PMEL) (Premelanosome Protein (PMEL))
    Reaktivität
    • 87
    • 12
    • 5
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 49
    • 36
    • 1
    Maus
    Klonalität
    • 48
    • 38
    • 1
    Monoklonal
    Konjugat
    • 46
    • 6
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Melanoma gp100 Antikörper ist unkonjugiert
    Applikation
    • 39
    • 37
    • 36
    • 34
    • 23
    • 14
    • 9
    • 5
    • 2
    • 2
    • 1
    Immunofluorescence (IF), Immunohistochemistry (IHC), Flow Cytometry (FACS), Western Blotting (WB)
    Verwendungszweck
    Mouse anti-Human gp100 Antibody [Sodium Azide Free]
    Spezifität
    Cytoplasmic
    Aufreinigung
    The extract of pigmented melanoma metastases from lymph nodes was used as the immunogen for this gp100 antibody.
    Immunogen
    The extract of pigmented melanoma metastases from lymph nodes was used as the immunogen for this gp100 antibody.
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    Discover our top product PMEL Primärantikörper
  • Applikationshinweise
    Western Blot: 1-2 μg/mL
    FACS:0.5-1 μg/million cells
    IF: 0.5-1 μg/mL
    IHC (FFPE): 0.5-1.0 μg/mL for 30 minutes at RT (1)
    Prediluted format: incubate for 30 min at RT (2)
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    In 1X PBS ( pH 7.4), BSA free, sodium azide free
    Konservierungsmittel
    Azide free
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
  • Target
    Melanoma gp100 (PMEL) (Premelanosome Protein (PMEL))
    Andere Bezeichnung
    Melanocyte protein PMEL , M-beta] (PMEL Produkte)
    Synonyme
    D12S53E antikoerper, ME20 antikoerper, ME20-M antikoerper, ME20M antikoerper, P1 antikoerper, P100 antikoerper, PMEL17 antikoerper, SI antikoerper, SIL antikoerper, SILV antikoerper, gp100 antikoerper, D10H12S53E antikoerper, D12S53Eh antikoerper, Pmel17 antikoerper, Si antikoerper, Silv antikoerper, gp87 antikoerper, RPE1 antikoerper, MMP115 antikoerper, silverb antikoerper, silver antikoerper, cb397 antikoerper, fdv antikoerper, pmel17 antikoerper, sb:cb397 antikoerper, silva antikoerper, wu:fc11g11 antikoerper, wu:fj24g11 antikoerper, zgc:136622 antikoerper, premelanosome protein antikoerper, premelanosome protein b antikoerper, premelanosome protein a antikoerper, PMEL antikoerper, Pmel antikoerper, pmelb antikoerper, pmela antikoerper
    Hintergrund

    Target Description: Melanocytes produce organelles called melanosomes which produce melanin, the pigment that gives color to skin, hair, eyes, scales and feathers. gp100 was identified in an attempt to clone the gene Tyrosinase, an enzyme required for melanin synthesis. Further testing determined that gp100 is a melanoma-specific protein and is responsible for melanosome maturation, facilitating the transition from amorphous rounded vesicles to fibrillary ellipsoid organelles.
    Metastatic amelanotic melanoma can often be confused with a variety of poorly differentiated carcinomas, large cell lymphomas, and sarcomas using H & E stains alone. It is also difficult to differentiate melanoma from spindle cell carcinomas and various types of mesenchymal neoplasms. Clone HMB45 gp100 antibody stains fetal and neonatal melanocytes, junctional and blue nevus cells, and malignant melanoma. It also stains angiomyolipomas, tumors most commonly associated with the kidney. Intradermal nevi, normal adult melanocytes, and non-melanocytic cells are negative. This gp100 antibody does not stain tumor cells of epithelial, lymphoid, glial, or mesenchymal origin.

    Gene Symbol: PMEL///D12S53E///PMEL17///SILV

    Gen-ID
    6490
    UniProt
    P40967
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