Melanoma gp100 Antikörper (N-Term)

Produktnummer ABIN2782746

Zitiert in 1 Publikation. Der Kaninchen Polyklonal anti-Melanoma gp100 Antikörper (ABIN2782746) detektiert spezifisch Melanoma gp100 in IHC, WB und IP. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Ratte, Maus, Pferd, Hund, Rind (Kuh), Ziege, Meerschweinchen und Kaninchen.

Kurzübersicht für Melanoma gp100 Antikörper (N-Term) (ABIN2782746)

Target: Melanoma gp100 (PMEL) (Premelanosome Protein (PMEL))

Reaktivität: Human, Ratte, Maus, Pferd, Hund, Rind (Kuh), Ziege, Meerschweinchen, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Melanoma gp100 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Western Blotting (WB), Immunoprecipitation (IP)

Produktdetails anti-Melanoma gp100 Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: SILV Antibody - N-terminal region

Sequenz: HFLRNQPLTF ALQLHDPSGY LAEADLSYTW DFGDSSGTLI SRALVVTHTY

Homologie: Cow: 93%, Dog: 86%, Goat: 93%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 86%, Rat: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against SILV. It was validated on Western Blot and immunohistochemistry.

Aufreinigung: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human SILV

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP46802-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.0 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-Melanoma gp100 Antikörper (ABIN2782746)

Theos, Truschel, Tenza, Hurbain, Harper, Berson, Thomas, Raposo, Marks: "A lumenal domain-dependent pathway for sorting to intralumenal vesicles of multivesicular endosomes involved in organelle morphogenesis." in: Developmental cell, Vol. 10, Issue 3, pp. 343-54, (2006) (PubMed).

Details zu Melanoma gp100

Target: Melanoma gp100 (PMEL) (Premelanosome Protein (PMEL))

Andere Bezeichnung: SILV

Hintergrund:

Background Information: SILV could be a melanogenic enzyme. It could represent an oncofetal self-antigen that is normally expressed at low levels in quiescent adult melanocytes but overexpressed by proliferating neonatal melanocytes and during tumor growth. Release of the soluble form, ME20-S, it could protect tumor cells from antibody mediated immunity.

Gene Name: Premelanosome protein

Alternative Symbols: P1, SI, SIL, ME20, P100, SILV, ME20M, gp100, ME20-M, PMEL17, D12S53E

Protein Name: Melanocyte protein PMEL

Molekulargewicht: 70kDa

Gen-ID: 6490

NCBI Accession: NP_008859

UniProt: P40967