CD3 epsilon Antikörper

Produktnummer ABIN6297680

Der Maus Monoklonal Anti-CD3 epsilon-Antikörper wurde für FACS, IF, Func, Act und ProA validiert. Er ist geeignet, CD3 epsilon in Proben von Human und Affe zu detektieren.

Kurzübersicht für CD3 epsilon Antikörper (ABIN6297680)

Target: CD3 epsilon (CD3E)

Reaktivität: Human, Affe

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD3 epsilon Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Immunofluorescence (IF), Functional Studies (Func), Activation (Act), Proliferation Assay (ProA)

Produktdetails anti-CD3 epsilon Antikörper

Verwendungszweck: Mouse anti-Human/Monkey CD3e Antibody [Sodium Azide Free]

Spezifität: Cell surface and cytoplasmic

Aufreinigung: Stimulated human leukocytes were used as the immunogen for the CD3e antibody.

Immunogen: Stimulated human leukocytes were used as the immunogen for the CD3e antibody.

Anwendungsinformationen

Applikationshinweise: Functional Activity: Induce T cell activation and proliferation (Order SAF formulation)
Flow Cytometry: 0.5-1 μg/million cells in 0.1ml
Immunofluorescence: 1-2 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: In 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Details zu CD3 epsilon

Target: CD3 epsilon (CD3E)

Andere Bezeichnung: T-cell surface glycoprotein CD3 epsilon chain

Hintergrund:

Target Description: Recognizes the epsilon-chain of CD3 (Workshop V, Code: CD03.09), which consists of five different polypeptide chains (designated as gamma, delta, epsilon, zeta, and eta) with MW ranging from 16-28 kDa. The CD3 complex is closely associated at the lymphocyte cell surface with the T cell antigen receptor (TCR). Reportedly, CD3 complex is involved in signal transduction to the T cell interior following antigen recognition. The CD3 antigen is first detectable in early thymocytes and probably represents one of the earliest signs of commitment to the T cell lineage. In cortical thymocytes, CD3 is predominantly intra-cytoplasmic. However, in medullary thymocytes, it appears on the T cell surface. CD3 antigen is a highly specific marker for T cells, and is present in majority of T cell neoplasms.

Gene Symbol: CD3E///T3E

Gen-ID: 916

UniProt: P07766

Pathways: T-Zell Rezeptor Signalweg, CXCR4-mediated Signaling Events, Ubiquitin Proteasome Pathway