ANO1 Antikörper

Produktnummer ABIN6297578

Der Maus Monoklonal Anti-ANO1-Antikörper wurde für IHC validiert. Er ist geeignet, ANO1 in Proben von Human zu detektieren.

Kurzübersicht für ANO1 Antikörper (ABIN6297578)

Target: ANO1 (Anoctamin 1, Calcium Activated Chloride Channel (ANO1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser ANO1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Produktdetails anti-ANO1 Antikörper

Verwendungszweck: Mouse anti-Human TMEM16A Antibody (DOG1) [IHC only]

Spezifität: Cell Surface and Cytoplasmic

Aufreinigung: Recombinant human TMEM16A/DOG1 protein was used as the immunogen for this TMEM16A antibody.

Immunogen: Recombinant human TMEM16A/DOG1 protein was used as the immunogen for this TMEM16A antibody.

Anwendungsinformationen

Applikationshinweise: Prediluted format : incubate for 30 min at RT (2)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Prediluted in 1X PBS ( pH 7.4) with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide, For IHC use only

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Details zu ANO1

Target: ANO1 (Anoctamin 1, Calcium Activated Chloride Channel (ANO1))

Andere Bezeichnung: Anoctamin-1

Hintergrund:

Target Description: Expression of TMEM16A (DOG1) protein is elevated in the gastrointestinal stromal tumors (GIST 's), c-kit signaling-driven mesenchymal tumors of the GI tract. It is rarely expressed in other soft tissue tumors, which, due to appearance, may be difficult to diagnose. Immunoreactivity for TMEM16A has been reported in 97.8 percent of scorable GIST 's, including all c-kit negative GIST 's. Overexpression has been suggested to aid in the identification of GISTs, including Platelet-Derived Growth Factor Receptor Alpha (PDGFR alpha) mutants that fail to express c-kit antigen. The overall sensitivity of TMEM16A and c-kit in GIST 's is nearly identical: 94.4 % vs. 94.7 %.

Gene Symbol: ANO1///DOG1///ORAOV2///TAOS2///TMEM16A

Gen-ID: 55107

UniProt: Q5XXA6