SUMO3 Antikörper

Produktnummer ABIN6297569

Der Maus Monoklonal Anti-SUMO3-Antikörper wurde für IHC validiert. Er ist geeignet, SUMO3 in Proben von Human zu detektieren.

Kurzübersicht für SUMO3 Antikörper (ABIN6297569)

Target: SUMO3 (Small Ubiquitin Related Modifier 3 (SUMO3))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser SUMO3 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Produktdetails anti-SUMO3 Antikörper

Verwendungszweck: Mouse anti-Human SUMO2/3 Antibody [IHC only]

Spezifität: Predominantly nuclear with some cytoplasmic

Aufreinigung: Recombinant human SUMO2 protein was used as the immunogen for this SUMO2/3 antibody.

Immunogen: Recombinant human SUMO2 protein was used as the immunogen for this SUMO2/3 antibody.

Anwendungsinformationen

Applikationshinweise: Prediluted format : incubate for 30 min at RT (2)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Prediluted in 1X PBS ( pH 7.4) with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide, For IHC use only

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Details zu SUMO3

Target: SUMO3 (Small Ubiquitin Related Modifier 3 (SUMO3))

Andere Bezeichnung: Small ubiquitin-related modifier 3

Hintergrund:

Target Description: This antibody reacts with both SUMO2 and SUMO3. The small ubiquitin-related modifier (SUMO) proteins, which include SUMO1, 2 and 3, belong to the ubiquitin-like protein family. Like ubiquitin, the SUMO proteins are synthesized as precursors that undergo processing before conjugation to target proteins. Also, both utilize the E1, E2 and E3 cascade enzymes for conjugation. However, SUMO and ubiquitin differ with respect to targeting. Ubiquitination predominantly targets proteins for degradation, whereas sumoylation targets for a variety of cellular processing, including nuclear transport, transcriptional regulation, apoptosis and protein stability. The unconjugated SUMO1/2/3 proteins localize to the nuclear membrane, nuclear bodies and cytoplasm, respectively. SUMO1 utilizes Ubc9 for conjugation to several targets, which include MDM2, p53, PML and RanGap1. SUMO2/3 contribute to a greater percentage of protein modification than does SUMO1 and they can form polymeric chains. In addition, SUMO3 regulates beta-Amyloid generation and may be critical in the onset or progression of Alzheimer 's disease.

Gene Symbol: SUMO3///SMT3A///SMT3H1

Gen-ID: 6613

UniProt: P55854