beta-2 Microglobulin Antikörper

Produktnummer ABIN6296700

Der Maus Monoklonal anti-beta-2 Microglobulin Antikörper (ABIN6296700) detektiert spezifisch beta-2 Microglobulin in FACS, IF, IP und IHC (fro). Dieser Antikörper reagiert spezifisch mit Proben aus Human und Non-Human Primate.

Kurzübersicht für beta-2 Microglobulin Antikörper (ABIN6296700)

Target: beta-2 Microglobulin (B2M) (beta-2-Microglobulin (B2M))

Reaktivität: Human, Non-Human Primate

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser beta-2 Microglobulin Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-beta-2 Microglobulin Antikörper

Verwendungszweck: Mouse anti-Human/non-Human primates Beta-2 Microglobulin Antibody [Sodium Azide Free]

Spezifität: Cytoplasmic

Aufreinigung: MOLT-4 human T cell line was used as the immunogen for the Beta-2 Microglobulin antibody.

Immunogen: MOLT-4 human T cell line was used as the immunogen for the Beta-2 Microglobulin antibody.

Anwendungsinformationen

Applikationshinweise: Flow Cytometry: 0.5-1 μg/million cells in 0.1ml
Immunofluorescence: 0.5-1 μg/mL
Immunoprecipitation: 2 μg/mg of lysate
Immunohistochemistry (Frozen): 0.5-1 μg/mL for 30 min at RT

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: In 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Details zu beta-2 Microglobulin

Target: beta-2 Microglobulin (B2M) (beta-2-Microglobulin (B2M))

Andere Bezeichnung: Beta-2-microglobulin

Hintergrund:

Target Description: Recognizes a protein of 12 kDa, identified as microglobulin. Major histocompatibility complex (MHC) class 1 Molecules bind to antigens for presentation on the surface of cells. The proteasome is responsible for producing these antigens from the components of foreign pathogens. MHC class 1 Molecules consist of an alpha- heavy chain that contains three subdomains (alpha-1, alpha-2, alpha-3) and a non-covalent associating light chain, known as beta-2-Microglobulin. Beta-2-Microglobulin associates with the alpha-3 subdomain of the alpha- heavy chain and forms an immunoglobulin domain-like structure that mediates proper folding and expression of MHC class 1 Molecules. The alpha-1 and alpha-2 domains of the alpha- heavy chain form the peptide antigen-binding cleft. Mutations in the beta-2-Microglobulin gene can enhance the progression of malignant melanoma phenotypes.

Gene Symbol: B2M///CDABP0092///HDCMA22P

Gen-ID: 567

UniProt: P61769

Pathways: T-Zell Rezeptor Signalweg, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process