Fascin Antikörper

Produktnummer ABIN6296304

Dieses Anti-Fascin-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von Fascin in IHC, FACS und IF. Geeignet für Human und Ratte.

Kurzübersicht für Fascin Antikörper (ABIN6296304)

Target: Fascin (FSCN1)

Reaktivität: Human, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Fascin Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunofluorescence (IF)

Produktdetails anti-Fascin Antikörper

Verwendungszweck: Mouse anti-Human/Rat Fascin Antibody [Sodium Azide Free]

Spezifität: Cytoplasmic

Aufreinigung: Full length recombinant human protein was used as the immunogen for the Fascin antibody.

Immunogen: Full length recombinant human protein was used as the immunogen for the Fascin antibody.

Anwendungsinformationen

Applikationshinweise: Flow Cytometry: 0.5-1 μg/million cells in 0.1ml
Immunofluorescence: 1-2 μg/mL
Immunohistology (FFPE): 0.5-1.0 μg/mL for 30 minutes at RT (1)
Prediluted format: incubate for 30 min at RT (2)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: In 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Details zu Fascin

Target: Fascin (FSCN1)

Andere Bezeichnung: Fascin

Hintergrund:

Target Description: Fascin/FSCN1 binds beta-catenin and colocalizes with it at the leading edges and borders of epithelial and endothelial cells. The role of FSCN1 in regulating cytoskeletal structures for the maintenance of cell adhesion, coordinating motility and invasion through interactions with signalling pathways is an active area of research especially from the cancer biology perspective. It localizes to actin-rich protrusions at the cell surface called filopodia. FSCN1 localizes to invadopodia, membrane protrusions formed at the adherent cell surface that facilitate extracellular matrix (ECM) invasion, this provide a potential molecular mechanism for how fascin increases the invasiveness of cancer cells since fascin expression is upregulated in a spectrum of cancers. [Wiki]

Gene Symbol: FSCN1///FAN1///HSN///SNL

Gen-ID: 6624

UniProt: Q16658