NUMA1 Antikörper

Produktnummer ABIN6296230

Dieses Maus Monoklonal-Antikörper erkennt spezifisch NUMA1 in WB, IHC und IF. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für NUMA1 Antikörper (ABIN6296230)

Target: NUMA1 (Nuclear Mitotic Apparatus Protein 1 (NUMA1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser NUMA1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-NUMA1 Antikörper

Verwendungszweck: Mouse anti-Human NuMA Antibody [Sodium Azide Free]

Spezifität: Nuclear

Aufreinigung: Colon carcinoma 174T cells were used as the immunogen for the NuMA antibody.

Immunogen: Colon carcinoma 174T cells were used as the immunogen for the NuMA antibody.

Anwendungsinformationen

Applikationshinweise: Western blot: 1-2 μg/mL
Immunofluorescence: 0.5-1 μg/mL
Immunohistochemistry (FFPE): 0.5-1 μg/mL for 30 min at RT (1)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: In 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Details zu NUMA1

Target: NUMA1 (Nuclear Mitotic Apparatus Protein 1 (NUMA1))

Andere Bezeichnung: Nuclear mitotic apparatus protein 1

Hintergrund:

Target Description: Recognizes a phosphorylated protein of 228 kDa, identified as nuclear mitotic apparatus protein (NuMA). Its epitope is resistant to phosphatases. NuMA is intra-nuclear protein and present in nucleus during interphase. At the onset of mitosis, it redistributes from the nucleus to two centrosomal structures that later will become part of the mitotic spindle pole. After anaphase, the protein redistributes from the spindle polar region into reforming nucleus. NuMA is an essential protein during mitosis for the terminal phases of chromosome separation and/or nuclear reassembly. Recently a study shows that NuMA is cleaved to a 180 to 200 kDa during apoptosis. Chromosomal translocation of this gene with the RARA (retinoic acid receptor, alpha) gene on chromosome 17 has been detected in patients with acute promyelocytic leukemia.

Gene Symbol: NUMA1///NMP22///NUMA

Gen-ID: 4926

UniProt: Q14980

Pathways: Caspase Kaskade in der Apoptose, Regulation of Actin Filament Polymerization, M Phase