TNFSF15 Antikörper

Produktnummer ABIN6295967

Der Maus Monoklonal Anti-TNFSF15-Antikörper wurde für WB, IHC, IF und FACS validiert. Er ist geeignet, TNFSF15 in Proben von Human zu detektieren.

Kurzübersicht für TNFSF15 Antikörper (ABIN6295967)

Target: TNFSF15 (Tumor Necrosis Factor (Ligand) Superfamily, Member 15 (TNFSF15))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TNFSF15 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)

Produktdetails anti-TNFSF15 Antikörper

Verwendungszweck: Mouse anti-Human VEGI / TL1A Antibody [Sodium Azide Free]

Spezifität: Cytoplasmic, cell surface, secreted

Aufreinigung: A full length human recombinant protein was used as the immunogen for this TL1A antibody.

Immunogen: A full length human recombinant protein was used as the immunogen for this TL1A antibody.

Anwendungsinformationen

Applikationshinweise: FACS: 0.5-1 μg/10^6 cells
IF: 1-2 μg/mL
Western blot: 1-2 μg/mL
IHC (FFPE): 1-2 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: In 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Details zu TNFSF15

Target: TNFSF15 (Tumor Necrosis Factor (Ligand) Superfamily, Member 15 (TNFSF15))

Andere Bezeichnung: Tumor necrosis factor ligand superfamily member 15

Hintergrund:

Target Description: TNF ligand-related molecule 1 is an anti-angiogenic cytokine that is also called Tumor necrosis factor superfamily, member 15 (TNFSF15) and Vascular endothelial growth inhibitor (VEGI/VEGI192A). This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Reduced expression of TL1A has been reported as a marker of poor prognosis in breast cancer.

Gene Symbol: TNFSF15///TL1///VEGI

Gen-ID: 9966

UniProt: O95150

Pathways: Positive Regulation of Endopeptidase Activity, Autophagie