Chromogranin A Antikörper

Produktnummer ABIN6295897

Dieser Maus Monoklonal Antikörper detektiert spezifisch Chromogranin A in IHC, IF und FACS. Es zeigt Reaktivität gegenüber Proben von Human, Ratte, Maus, Affe und Schwein.

Kurzübersicht für Chromogranin A Antikörper (ABIN6295897)

Target: Chromogranin A (CHGA)

Reaktivität: Human, Ratte, Maus, Affe, Schwein

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Chromogranin A Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)

Produktdetails anti-Chromogranin A Antikörper

Verwendungszweck: Mouse anti-Human/Monkey/Pig/Mouse/Rat Chromogranin A Antibody Cocktail [Sodium Azide Free]

Spezifität: Finely granular cytoplasmic

Aufreinigung: Human pheochromocytoma cells (LK2H10 + PHE5) and recombinant human Chromogranin A protein (CGA414) were used as the immunogen for this antibody.

Immunogen: Human pheochromocytoma cells (LK2H10 + PHE5) and recombinant human Chromogranin A protein (CGA414) were used as the immunogen for this antibody.

Anwendungsinformationen

Applikationshinweise: FACS: 0.5-1 μg/million cells
IF: 1-2 μg/mL
IHC (FFPE): 0.5-1 μg/mL for 30 minutes at RT (1)
Prediluted format: incubate for 30 min at RT (2)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: In 1X PBS ( pH 7.4), BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Details zu Chromogranin A

Target: Chromogranin A (CHGA)

Andere Bezeichnung: Chromogranin-A , AL-11, GV-19, GR-44, ER-37, GE-25, Serpinin-RRG, Serpinin, p-Glu serpinin precursor]

Hintergrund:

Target Description: Chromogranin A is present in neuroendocrine cells throughout the body, including the neuroendocrine cells of the large and small intestine, adrenal medulla and pancreatic islets. It is an excellent marker for carcinoid tumors, pheochromocytomas, paragangliomas, and other neuroendocrine tumors. Co-expression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms. Reportedly, co-expression of certain keratins and chromogranin indicates neuroendocrine lineage. The presence of strong anti-chromogranin staining and absence of anti-keratin staining should raise the possibility of paraganglioma. The co-expression of chromogranin and NSE is typical of neuroendocrine neoplasms. Most pituitary adenomas and prolactinomas readily express chromogranin.

Gene Symbol: CHGA

Gen-ID: 1113

UniProt: P10645

Pathways: Negative Regulation of Hormone Secretion, cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling