LHCGR Antikörper (N-Term)

Produktnummer ABIN6295471

Dieser Maus Monoklonal Antikörper detektiert spezifisch LHCGR in IF, FACS und IHC. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für LHCGR Antikörper (N-Term) (ABIN6295471)

Target: LHCGR (Luteinizing Hormone/Choriogonadotropin Receptor (LHCGR))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser LHCGR Antikörper ist unkonjugiert

Applikation: Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (IHC)

Produktdetails anti-LHCGR Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: Mouse anti-Human hCG Receptor / LH Receptor Antibody [Sodium Azide Free]

Spezifität: Cytoplasmic, cell surface

Aufreinigung: A partial recombinant protein from the N-terminal region of human Luteinizing hormone / Choriogonadotropin receptor was used as the immunogen for the LHR antibody.

Immunogen: A partial recombinant protein from the N-terminal region of human Luteinizing hormone / Choriogonadotropin receptor was used as the immunogen for the LHR antibody.

Anwendungsinformationen

Applikationshinweise: FACS: 0.5-1 μg/million cells in 0.1ml
IF: 1-2 μg/mL
IHC (FFPE): 0.5-1 μg/mL for 30 min at RT

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: In 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Details zu LHCGR

Target: LHCGR (Luteinizing Hormone/Choriogonadotropin Receptor (LHCGR))

Andere Bezeichnung: Lutropin-choriogonadotropic hormone receptor

Hintergrund:

Target Description: Recognizes a protein of 78-85 kDa, which is identified as the receptor for Luteinizing hormone / Choriogonadotropin (LHR/CGR). Luteinizing hormone plays a role in spermatogenesis and ovulation by stimulating the testes and ovaries to produce steroids. Choriogonadotropin production in the placenta maintains estrogen and progesterone levels during the first trimester of pregnancy. Ovaries and testes abundantly express luteinizing hormone / choriogonadotropin receptor (LHCGR) as a seven transmembrane, G protein-coupled receptor glycoprotein. LHCGR influences the protective effect of pregnancy and Gonadotropin against breast cancer. The expression of LHCGR on breast carcinoma correlates in part to the degree of tumor differentiation. LHCGR -positive breast tumors occur more frequently in tumors with greater cell differentiation in premenopausal women.

Gene Symbol: LHCGR///LCGR///LGR2///LHRHR

Gen-ID: 3973

UniProt: P22888

Pathways: Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, cAMP Metabolic Process, Glycosaminoglycan Metabolic Process, Regulation of Carbohydrate Metabolic Process, Autophagie, Negative Regulation of intrinsic apoptotic Signaling