Desmocollin 2 Antikörper (Extracellular Domain)

Produktnummer ABIN6295454

Der Maus Monoklonal Anti-Desmocollin 2-Antikörper wurde für WB, IHC, IF und FACS validiert. Er ist geeignet, Desmocollin 2 in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für Desmocollin 2 Antikörper (Extracellular Domain) (ABIN6295454)

Target: Desmocollin 2 (DSC2)

Reaktivität: Human, Maus, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Desmocollin 2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)

Produktdetails anti-Desmocollin 2 Antikörper

Bindungsspezifität: Extracellular Domain

Verwendungszweck: Mouse anti-Human/Mouse/Rat Desmocollin 2/3 Antibody [Sodium Azide Free]

Spezifität: Cell surface

Aufreinigung: A recombinant protein corresponding to the extracellular domain of human Desmocollin 2 was used as the immunogen for the Desmocollin 2/3 antibody.

Immunogen: A recombinant protein corresponding to the extracellular domain of human Desmocollin 2 was used as the immunogen for the Desmocollin 2/3 antibody.

Anwendungsinformationen

Applikationshinweise: WB: 0.5-1 μg/mL
FACS: 0.5-1 μg/million cells in 0.1ml
Immunofluorescence: 1-2 μg/mL
Immunohistochemistry (FFPE): 1-2 μg/mL for 30 min at RT

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: In 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Details zu Desmocollin 2

Target: Desmocollin 2 (DSC2)

Andere Bezeichnung: Desmocollin-2

Hintergrund:

Target Description: Desmosomes are intercellular adhering junctions that represent cell surface attachment sites for intermediate filament. The desmosome is subdivided into two regions. The plaque region lies adjacent to the plasma, and is believed to contain molecules that attach the intermediate filament cytoskeleton to the desmosome. The core region is composed of transmembrane glycoproteins that are thought to mediate cell-cell adhesion. Desmogleins and desmocollins are the main desmosomal transmembrane proteins. These desmosomal glycoproteins belong to the members of the cadherin family of adhesion molecules. Three different isoforms of both desmogleins and desmocollins have been identified, named as desmoglein 1-3 and desmocollins. Desmosomal cadherins showed differentiation-specific expression in the human epidermis, although the functional significance of this differential expression is not fully understood. Desmocollin-1 can be found in the upper layers. The expression of Desmocollin-2 varies in the basal and suprabasal layers. And Desmocollin-3 is expressed more evenly throughout the suprabasal layers.

Gene Symbol: DSC2///CDHF2///DSC3

Gen-ID: 1824

UniProt: Q02487