Aurora Kinase B Antikörper (AA 89-251)

Produktnummer ABIN6294603

Dieses Anti-Aurora Kinase B-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von Aurora Kinase B in WB, IF und FACS. Geeignet für Human.

Kurzübersicht für Aurora Kinase B Antikörper (AA 89-251) (ABIN6294603)

Target: Aurora Kinase B (AURKB)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Aurora Kinase B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)

Produktdetails anti-Aurora Kinase B Antikörper

Bindungsspezifität: AA 89-251

Verwendungszweck: Mouse anti-Human Aurora B Antibody / AURKB [Sodium Azide Free]

Spezifität: Nuclear, cytoplasmic

Aufreinigung: Amino acids 89-251 were used as the immunogen for this Aurora B antibody.

Immunogen: Amino acids 89-251 were used as the immunogen for this Aurora B antibody.

Anwendungsinformationen

Applikationshinweise: Western blot: 0.5-1 μg/mL
FACS: 0.5-1 μg/10e6 cells in 0.1ml
IF: 1-2 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: In 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Details zu Aurora Kinase B

Target: Aurora Kinase B (AURKB)

Andere Bezeichnung: Aurora kinase B

Hintergrund:

Target Description: Recognizes a protein of 39-45 kDa, which is identified as Aurora B. The serine/threonine protein kinase aurora B (Aurora B) is a chromosomal passenger protein critical for accurate chromosome segregation, cytokinesis, protein localization to the centromere and kinetochore, correct microtubule-kinetochore attachment, and regulation of the mitotic checkpoint. Aurora B forms a tight complex with inner centrosome protein and survivin. Inactivation of any of these proteins causes similar defects in chromosome segregation. A significant overexpression of Aurora B has been found in a variety of human tumors including non-small cell lung carcinoma, astrocytoma, seminoma and carcinomas of the colon, prostate, endometrium and thyroid. The expression level of Aurora B is associated with cell proliferation and prognosis in these tumors.

Gene Symbol: AURKB///AIK2///AIM1///AIRK2///ARK2///STK1///STK12///STK5

Gen-ID: 9212

UniProt: Q96GD4

Pathways: T-Zell Rezeptor Signalweg, Zellzyklus, Maintenance of Protein Location, Hepatitis C, Toll-Like Receptors Cascades