POMC Antikörper (AA 1-24)

Produktnummer ABIN6294238

Dieses Maus Monoklonal-Antikörper erkennt spezifisch POMC in IHC, FACS und IF. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.

Kurzübersicht für POMC Antikörper (AA 1-24) (ABIN6294238)

Target: POMC (Proopiomelanocortin (POMC))

Reaktivität: Human, Maus, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser POMC Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunofluorescence (IF)

Produktdetails anti-POMC Antikörper

Bindungsspezifität: AA 1-24

Verwendungszweck: Mouse anti-Human/Mouse/Rat ACTH Antibody [Sodium Azide Free]

Spezifität: Cytoplasmic

Aufreinigung: A synthetic peptide corresponding to aa 1-24 of human ACTH was used as the immunogen for this ACTH antibody.

Immunogen: A synthetic peptide corresponding to aa 1-24 of human ACTH was used as the immunogen for this ACTH antibody.

Anwendungsinformationen

Applikationshinweise: FACS: 0.5-1 μg/million cells
IF: 1-2 μg/mL
IHC (FFPE): 0.5-1 μg/mL for 30 minutes at RT (1)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: In 1X PBS ( pH 7.4), BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Details zu POMC

Target: POMC (Proopiomelanocortin (POMC))

Andere Bezeichnung: Pro-opiomelanocortin , Beta-endorphin, Met-enkephalin]

Hintergrund:

Target Description: POMC (pro-opiomelanocortin or corticotropin-lipotropin) is a 267 amino acid polypeptide hormone precursor that goes through extensive, tissue-specific post-translational processing by convertases. POMC is cleaved into ten hormone chains named NPP, ACTH, alpha-MSH (Melanocyte Stimulating Hormone), beta-MSH, gamma-MSH, CLIP (corticotropin-like intermediary peptide), Lipotropin-beta, Lipotropin-gamma, beta-endorphin and Met-enkephalin. ACTH (also called Corticotropin) is a 39 amino acid active peptide produced by the anterior pituitary. Clone AH26 antibody is specific to Synacthen (aa 1-24 of ACTH) and does not react with CLIP (aa 17-39). ACTH is produced by cells of immune system (T-cells, B-cells, and macrophages) in response to stimuli associated with stress. Specific antibody is a useful marker in classification of pituitary tumors and the study of pituitary disease. It reacts with ACTH-producing cells (corticotrophs). It also may react with other tumors (e.g. some small cell carcinomas of the lung) that cause paraneoplastic syndromes by secreting ACTH.

Gene Symbol: POMC

Gen-ID: 5443

UniProt: P01189

Pathways: Metabolism of Steroid Hormones and Vitamin D, Peptide Hormone Metabolism, Hormone Activity, Feeding Behaviour