Histone Cluster 2, H4a (HIST2H4A) (Lys20) Antikörper

Produktnummer ABIN6266164

Der Kaninchen Polyklonal anti-Histone Cluster 2, H4a Antikörper (ABIN6266164) detektiert spezifisch Histone Cluster 2, H4a in WB, ELISA, ICC, ChIP, IF und IP. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für Histone Cluster 2, H4a (HIST2H4A) (Lys20) Antikörper (ABIN6266164)

Target: Histone Cluster 2, H4a (HIST2H4A)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Chromatin Immunoprecipitation (ChIP), Immunofluorescence (IF), Immunoprecipitation (IP)

Produktdetails

Bindungsspezifität: Lys20

Spezifität: HIST2H4A Antibody detects endogenous levels of total HIST2H4A

Kreuzreaktivität: Human, Maus, Ratte (Rattus)

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthetic methylated peptide corresponding to residues surrounding K20 of human histone H4

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000 IF 1:50-1:200 IP 1:50-1:200 CHIP 1:50-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C.Stable for 12 months from date of receipt

Haltbarkeit: 12 months

Antigendetails

Target: Histone Cluster 2, H4a (HIST2H4A)

Andere Bezeichnung: HIST2H4A

Hintergrund:

Description: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Gene: HIST1H4A, HIST1H4B, HIST1H4C, HIST1H4D, HIST1H4E, HIST1H4F, HIST1H4H, HIST1H4I, HIST1H4J, HIST1H4K, HIST1H4L, HIST2H4A, HIST2H4B, HIST4H4

Molekulargewicht: 11kDa

Gen-ID: 121, 504, 554

UniProt: P62805

Pathways: Telomere Maintenance