SYNPO2 Antikörper (Internal Region)

Produktnummer ABIN6265395

Der Kaninchen Polyklonal Anti-SYNPO2-Antikörper wurde für IHC und WB validiert. Er ist geeignet, SYNPO2 in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für SYNPO2 Antikörper (Internal Region) (ABIN6265395)

Target: SYNPO2 (Synaptopodin 2 (SYNPO2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SYNPO2 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Western Blotting (WB)

Produktdetails anti-SYNPO2 Antikörper

Bindungsspezifität: Internal Region

Spezifität: Synaptopodin Antibody detects endogenous levels of total Synaptopodin.

Homologie: Bovine,Horse

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human Synaptopodin, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:50-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu SYNPO2

Target: SYNPO2 (Synaptopodin 2 (SYNPO2))

Andere Bezeichnung: SYNPO2

Hintergrund:

Description: Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:24005909, PubMed:23225103). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension, may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336).

Gene: SYNPO2

Molekulargewicht: 99-115 kDa

Gen-ID: 171024

UniProt: Q9UMS6