RNF5 Antikörper (C-Term)

Produktnummer ABIN6264790

Dieses Anti-RNF5-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von RNF5 in WB und ELISA. Geeignet für Human, Maus und Ratte.

Kurzübersicht für RNF5 Antikörper (C-Term) (ABIN6264790)

Target: RNF5 (Ring Finger Protein 5, E3 Ubiquitin Protein Ligase (RNF5))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RNF5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-RNF5 Antikörper

Bindungsspezifität: C-Term

Spezifität: RNF5 Antibody detects endogenous levels of total RNF5.

Homologie: Pig,Zebrafish,Bovine,Horse,Rabbit,Dog

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human RNF5, corresponding to a region within C-terminal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu RNF5

Target: RNF5 (Ring Finger Protein 5, E3 Ubiquitin Protein Ligase (RNF5))

Andere Bezeichnung: RNF5

Hintergrund:

Description: Has E2-dependent E3 ubiquitin-protein ligase activity. May function together with E2 ubiquitin-conjugating enzymes UBE2D1/UBCH5A and UBE2D2/UBC4. Mediates ubiquitination of PXN/paxillin and Salmonella type III secreted protein sopA. May be involved in regulation of cell motility and localization of PXN/paxillin. Mediates the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD, the ubiquitination appears to involve E2 ubiquitin-conjugating enzyme UBE2N. Mediates the 'Lys-48'-linked polyubiquitination of TMEM173 at 'Lys-150' leading to its proteasomal degradation, the ubiquitination occurs in mitochondria after viral transfection and regulates antiviral responses.

Gene: RNF5

Molekulargewicht: 20 kDa

Gen-ID: 6048

UniProt: Q99942