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PELP1 Antikörper (Internal Region)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch PELP1 in WB, IHC, ELISA, IF und ICC. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.
Produktnummer ABIN6264131

Kurzübersicht für PELP1 Antikörper (Internal Region) (ABIN6264131)

Target

Alle PELP1 Antikörper anzeigen
PELP1 (Proline-, Glutamic Acid- and Leucine-Rich Protein 1 (PELP1))

Reaktivität

  • 44
  • 36
  • 11
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
Human, Maus, Ratte

Wirt

  • 44
  • 8
Kaninchen

Klonalität

  • 39
  • 13
Polyklonal

Konjugat

  • 28
  • 5
  • 4
  • 3
  • 3
  • 3
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser PELP1 Antikörper ist unkonjugiert

Applikation

  • 35
  • 30
  • 16
  • 6
  • 4
  • 3
  • 3
  • 2
  • 2
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
  • Bindungsspezifität

    • 8
    • 6
    • 6
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region

    Spezifität

    PELP1 Antibody detects endogenous levels of total PELP1.

    Homologie

    Pig,Bovine,Horse,Sheep,Rabbit,Dog

    Aufreinigung

    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).

    Immunogen

    A synthesized peptide derived from human PELP1, corresponding to a region within the internal amino acids.

    Isotyp

    IgG
  • Applikationshinweise

    WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 mg/mL

    Buffer

    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20 °C. Stable for 12 months from date of receipt.

    Haltbarkeit

    12 months
  • Target

    PELP1 (Proline-, Glutamic Acid- and Leucine-Rich Protein 1 (PELP1))

    Andere Bezeichnung

    PELP1

    Hintergrund

    Description: Coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptors and sequence-specific transcription factors. Plays a role in estrogen receptor (ER) genomic activity when present in the nuclear compartment by activating the ER target genes in a hormonal stimulation dependent manner. Can facilitate ER non-genomic signaling via SRC and PI3K interaction in the cytosol. Plays a role in E2-mediated cell cycle progression by interacting with RB1. May have important functional implications in ER/growth factor cross-talk. Interacts with several growth factor signaling components including EGFR and HRS. Involved in nuclear receptor signaling via its interaction with AR and NR3C1. May promote tumorigenesis via its interaction with and modulation of several oncogenes including SRC, PI3K, STAT3 and EGFR. Plays a role in cancer cell metastasis via its ability to modulate E2-mediated cytoskeleton changes and cell migration via its interaction with SRC and PI3K. Functions as the key stabilizing component of the Five Friends of Methylated CHTOP (5FMC) complex, the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit. Regulates pre-60S association of the critical remodeling factor MDN1 (PubMed:21326211).

    Gene: PELP1

    Molekulargewicht

    119kDa

    Gen-ID

    27043

    UniProt

    Q8IZL8
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