PDIA6 Antikörper (C-Term)

Produktnummer ABIN6264114

Der Kaninchen Polyklonal Anti-PDIA6-Antikörper wurde für WB, IHC, IF und ICC validiert. Er ist geeignet, PDIA6 in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für PDIA6 Antikörper (C-Term) (ABIN6264114)

Target: PDIA6 (Protein Disulfide Isomerase Family A, Member 6 (PDIA6))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PDIA6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Produktdetails anti-PDIA6 Antikörper

Bindungsspezifität: C-Term

Spezifität: PDIA6 Antibody detects endogenous levels of total PDIA6.

Homologie: Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human PDIA6, corresponding to a region within C-terminal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu PDIA6

Target: PDIA6 (Protein Disulfide Isomerase Family A, Member 6 (PDIA6))

Andere Bezeichnung: PDIA6

Hintergrund:

Description: May function as a chaperone that inhibits aggregation of misfolded proteins (PubMed:12204115). Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling (PubMed:24508390). May also regulate the UPR via the EIF2AK3 UPR sensor (PubMed:24508390). Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin (PubMed:15466936).

Gene: PDIA6

Molekulargewicht: 54 kDa

Gen-ID: 10130

UniProt: Q15084

Pathways: ER-Nucleus Signaling, Cell RedoxHomeostasis