IL28B Antikörper

Produktnummer ABIN6262561

Dieses Anti-IL28B-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von IL28B in WB, ELISA und IHC. Geeignet für Human, Maus und Ratte.

Kurzübersicht für IL28B Antikörper (ABIN6262561)

Target: IL28B (Interleukin 28B (Interferon, lambda 3) (IL28B))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IL28B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-IL28B Antikörper

Spezifität: IL28B Antibody detects endogenous levels of total IL28B

Kreuzreaktivität: Human, Maus, Ratte (Rattus)

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human IL28B

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:1000-3000 IHC 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C.Stable for 12 months from date of receipt

Haltbarkeit: 12 months

Details zu IL28B

Target: IL28B (Interleukin 28B (Interferon, lambda 3) (IL28B))

Andere Bezeichnung: IL28B

Hintergrund:

Description: Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.

Gene: IFNL3

Molekulargewicht: 22 kDa

Gen-ID: 282617

UniProt: Q8IZI9, Q8IZJ0