HECTD1 Antikörper (Internal Region)
Kurzübersicht für HECTD1 Antikörper (Internal Region) (ABIN6262200)
Target
Alle HECTD1 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- Internal Region
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Verwendungszweck
- HECTD1 Antibody
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Spezifität
- HECTD1 Antibody detects endogenous levels of total HECTD1
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Homologie
- Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
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Aufreinigung
- The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
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Immunogen
- A synthesized peptide derived from human HECTD1, corresponding to a region within the internal amino acids.
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Isotyp
- IgG
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Applikationshinweise
- WB 1:1000-3000, IHC 1:50-1:200
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Konzentration
- 1 mg/mL
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Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- Store at -20 °C. Stable for 12 months from date of receipt.
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Haltbarkeit
- 12 months
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- HECTD1 (HECT Domain Containing 1 (HECTD1))
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Andere Bezeichnung
- HECTD1
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Hintergrund
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Description: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates 'Lys-63'-linked polyubiquitination of HSP90AA1 which leads to its intracellular localization and reduced secretion. Negatively regulating HSP90AA1 secretion in cranial mesenchyme cells may impair their emigration and may be essential for the correct development of the cranial neural folds and neural tube closure.
Gene: HECTD1
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Molekulargewicht
- 289kDa
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Gen-ID
- 25831
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UniProt
- Q9ULT8
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Pathways
- Tube Formation, SARS-CoV-2 Protein Interaktom, Phosphorylierungen bei SARS-CoV-2 Infektion
Target
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