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HDAC3 Antikörper (C-Term)

HDAC3 Reaktivität: Human, Maus, Ratte WB, ELISA, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6262179
  • Target Alle HDAC3 Antikörper anzeigen
    HDAC3 (Histone Deacetylase 3 (HDAC3))
    Bindungsspezifität
    • 22
    • 20
    • 16
    • 10
    • 8
    • 5
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reaktivität
    • 116
    • 66
    • 63
    • 9
    • 7
    • 6
    • 6
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 88
    • 27
    • 1
    Kaninchen
    Klonalität
    • 88
    • 28
    Polyklonal
    Konjugat
    • 67
    • 6
    • 6
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser HDAC3 Antikörper ist unkonjugiert
    Applikation
    • 101
    • 52
    • 39
    • 28
    • 27
    • 26
    • 16
    • 16
    • 15
    • 8
    • 7
    • 6
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Spezifität
    HDAC3 Antibody detects endogenous levels of total HDAC3.
    Homologie
    Pig,Zebrafish,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human HDAC3, corresponding to a region within C-terminal amino acids.
    Isotyp
    IgG
    Top Product
    Discover our top product HDAC3 Primärantikörper
  • Applikationshinweise
    WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C. Stable for 12 months from date of receipt.
    Haltbarkeit
    12 months
  • Target
    HDAC3 (Histone Deacetylase 3 (HDAC3))
    Andere Bezeichnung
    HDAC3 (HDAC3 Produkte)
    Synonyme
    CG2128 antikoerper, DHDAC3 antikoerper, DmHDAC3 antikoerper, Dmel\\CG2128 antikoerper, Dromel_CG2128_FBtr0078767_hdac3_mORF antikoerper, HDAC antikoerper, HDAC3 antikoerper, Hdac 3 antikoerper, dHDAC3 antikoerper, dmHDA402 antikoerper, hdac3 antikoerper, HDm antikoerper, hd3 antikoerper, RPD3 antikoerper, XRpd3 antikoerper, rpd3-2 antikoerper, HD3 antikoerper, RPD3-2 antikoerper, AW537363 antikoerper, zgc:55927 antikoerper, Histone deacetylase 3 antikoerper, histone deacetylase 3 antikoerper, histone deacetylase 3 S homeolog antikoerper, HDAC3 antikoerper, hdac3 antikoerper, CNL05260 antikoerper, Hdac3 antikoerper, hdac3.S antikoerper
    Hintergrund

    Description: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1, increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation (PubMed:21444723, PubMed:23911289). Contributes, together with XBP1 isoform 1, to the activation of NFE2L2-mediated HMOX1 transcription factor gene expression in a PI3K/mTORC2/Akt-dependent signaling pathway leading to endothelial cell (EC) survival under disturbed flow/oxidative stress (PubMed:25190803).

    Gene: HDAC3

    Molekulargewicht
    48kDa
    Gen-ID
    8841
    UniProt
    O15379
    Pathways
    Neurotrophin Signalübertragung, Regulation of Lipid Metabolism by PPARalpha, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development
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