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HDAC3 Antikörper (C-Term)

Der Kaninchen Polyklonal Anti-HDAC3-Antikörper wurde für WB, ELISA, IHC, IF und ICC validiert. Er ist geeignet, HDAC3 in Proben von Human, Maus und Ratte zu detektieren.
Produktnummer ABIN6262179

Kurzübersicht für HDAC3 Antikörper (C-Term) (ABIN6262179)

Target

Alle HDAC3 Antikörper anzeigen
HDAC3 (Histone Deacetylase 3 (HDAC3))

Reaktivität

  • 125
  • 76
  • 73
  • 9
  • 7
  • 6
  • 6
  • 5
  • 4
  • 4
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
Human, Maus, Ratte

Wirt

  • 97
  • 27
  • 1
Kaninchen

Klonalität

  • 95
  • 30
Polyklonal

Konjugat

  • 69
  • 5
  • 5
  • 4
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
Dieser HDAC3 Antikörper ist unkonjugiert

Applikation

  • 98
  • 50
  • 38
  • 29
  • 27
  • 26
  • 17
  • 16
  • 16
  • 9
  • 6
  • 6
  • 4
  • 2
  • 2
  • 2
  • 1
Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
  • Bindungsspezifität

    • 18
    • 16
    • 15
    • 11
    • 8
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term

    Spezifität

    HDAC3 Antibody detects endogenous levels of total HDAC3.

    Homologie

    Pig,Zebrafish,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

    Aufreinigung

    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).

    Immunogen

    A synthesized peptide derived from human HDAC3, corresponding to a region within C-terminal amino acids.

    Isotyp

    IgG
  • Applikationshinweise

    WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 mg/mL

    Buffer

    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20 °C. Stable for 12 months from date of receipt.

    Haltbarkeit

    12 months
  • Target

    HDAC3 (Histone Deacetylase 3 (HDAC3))

    Andere Bezeichnung

    HDAC3

    Hintergrund

    Description: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1, increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation (PubMed:21444723, PubMed:23911289). Contributes, together with XBP1 isoform 1, to the activation of NFE2L2-mediated HMOX1 transcription factor gene expression in a PI3K/mTORC2/Akt-dependent signaling pathway leading to endothelial cell (EC) survival under disturbed flow/oxidative stress (PubMed:25190803).

    Gene: HDAC3

    Molekulargewicht

    48kDa

    Gen-ID

    8841

    UniProt

    O15379

    Pathways

    Neurotrophin Signalübertragung, Regulation of Lipid Metabolism by PPARalpha, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development
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