Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

RAD51C Antikörper (Internal Region)

RAD51C Reaktivität: Human, Maus, Ratte WB, ELISA, IF, IHC, ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6259171
  • Target Alle RAD51C Antikörper anzeigen
    RAD51C (DNA Repair Protein RAD51 Homolog 3 (RAD51C))
    Bindungsspezifität
    • 10
    • 9
    • 8
    • 6
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reaktivität
    Human, Maus, Ratte
    Wirt
    • 37
    • 7
    • 1
    Kaninchen
    Klonalität
    • 39
    • 6
    Polyklonal
    Konjugat
    • 28
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser RAD51C Antikörper ist unkonjugiert
    Applikation
    • 35
    • 22
    • 11
    • 6
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC), Immunocytochemistry (ICC)
    Spezifität
    Rad51C Antibody detects endogenous levels of total Rad51C.
    Homologie
    Sheep
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human Rad51C, corresponding to a region within the internal amino acids.
    Isotyp
    IgG
    Top Product
    Discover our top product RAD51C Primärantikörper
  • Applikationshinweise
    WB 1:500-1:1000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C. Stable for 12 months from date of receipt.
    Haltbarkeit
    12 months
  • Target
    RAD51C (DNA Repair Protein RAD51 Homolog 3 (RAD51C))
    Andere Bezeichnung
    RAD51C (RAD51C Produkte)
    Synonyme
    RGD1563765 antikoerper, CG2412 antikoerper, Dm CG2412 antikoerper, Dmel\\CG2412 antikoerper, zgc:101596 antikoerper, RAD51C antikoerper, Rad51c antikoerper, ATRAD51C antikoerper, F4L23.21 antikoerper, RAS associated with diabetes protein 51C antikoerper, R51H3 antikoerper, Rad51l2 antikoerper, BROVCA3 antikoerper, FANCO antikoerper, RAD51L2 antikoerper, RAD51 paralog C antikoerper, Rad51 recombinase D antikoerper, Rad51 DNA recombinase 3 antikoerper, RAD51C protein antikoerper, RAD51 homolog C antikoerper, RAS associated with diabetes protein 51C antikoerper, RAD51C antikoerper, Rad51c antikoerper, Rad51D antikoerper, rad51c antikoerper
    Hintergrund

    Description: Essential for the homologous recombination (HR) pathway of DNA repair. Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Part of the RAD21 paralog protein complexes BCDX2 and CX3 which act at different stages of the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 seems to act downstream of BRCA2 recruitment and upstream of RAD51 recruitment, CX3 seems to act downstream of RAD51 recruitment, both complexes bind predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway. Involved in RAD51 foci formation in response to DNA damage suggesting an involvement in early stages of HR probably in the invasion step. Has an early function in DNA repair in facilitating phosphorylation of the checkpoint kinase CHEK2 and thereby transduction of the damage signal, leading to cell cycle arrest and HR activation. Participates in branch migration and HJ resolution and thus is important for processing HR intermediates late in the DNA repair process, the function may be linked to the CX3 complex. Part of a PALB2-scaffolded HR complex containing BRCA2 and which is thought to play a role in DNA repair by HR. Protects RAD51 from ubiquitin-mediated degradation that is enhanced following DNA damage. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and XRCC3. Contributes to DNA cross-link resistance, sister chromatid cohesion and genomic stability. Involved in maintaining centrosome number in mitosis.

    Gene: RAD51C

    Molekulargewicht
    50 kDa
    Gen-ID
    5889
    UniProt
    O43502
    Pathways
    DNA Reparatur
Sie sind hier:
Kundenservice