EPH Receptor A2 Antikörper (C-Term)

Produktnummer ABIN6258773

Produktdetails anti-EPH Receptor A2 Antikörper

Target: EPH Receptor A2 (EPHA2)

Bindungsspezifität: C-Term

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EPH Receptor A2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Spezifität: EPHA2 Antibody detects endogenous levels of total EPHA2.

Homologie: Pig,Horse,Rabbit,Dog

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human EPHA2, corresponding to a region within C-terminal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:1000, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu EPH Receptor A2

Target: EPH Receptor A2 (EPHA2)

Andere Bezeichnung: EPHA2 (EPHA2 Produkte)

Synonyme: ARCC2 antikoerper, CTPA antikoerper, CTPP1 antikoerper, CTRCT6 antikoerper, ECK antikoerper, epha2 antikoerper, MGC89505 antikoerper, AW545284 antikoerper, Eck antikoerper, Myk2 antikoerper, Sek-2 antikoerper, Sek2 antikoerper, id:ibd5152 antikoerper, rtk6 antikoerper, G42 antikoerper, XE10 antikoerper, epha2-A antikoerper, EPH receptor A2 antikoerper, Eph receptor A2 antikoerper, epoxide hydrolase antikoerper, eph receptor A2 a antikoerper, EPH receptor A2 L homeolog antikoerper, EPHA2 antikoerper, Epha2 antikoerper, epha2 antikoerper, ephA2 antikoerper, epha2a antikoerper, epha2.L antikoerper

Hintergrund:

Description: Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis.

Gene: EPHA2

Molekulargewicht: 105 kDa

Gen-ID: 1969

UniProt: P29317

Pathways: RTK Signalweg