ATG4C Antikörper (N-Term)

Produktnummer ABIN6258589

Dieses Anti-ATG4C-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von ATG4C in WB, ELISA, IHC, IF und ICC. Geeignet für Human und Maus.

Kurzübersicht für ATG4C Antikörper (N-Term) (ABIN6258589)

Target: ATG4C (Autophagy related 4C Cysteine Peptidase (ATG4C))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ATG4C Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Produktdetails anti-ATG4C Antikörper

Bindungsspezifität: N-Term

Spezifität: ATG4C Antibody detects endogenous levels of total ATG4C.

Homologie: Pig,Horse,Sheep,Rabbit

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human ATG4C, corresponding to a region within N-terminal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:1000, IHC: 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu ATG4C

Target: ATG4C (Autophagy related 4C Cysteine Peptidase (ATG4C))

Andere Bezeichnung: ATG4C

Hintergrund:

Description: Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Is not essential for autophagy development under normal conditions but is required for a proper autophagic response under stressful conditions such as prolonged starvation (By similarity). Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms.

Gene: ATG4C

Molekulargewicht: 49 kDa

Gen-ID: 84938

UniProt: Q96DT6

Pathways: Autophagie