USP44 Antikörper (Internal Region)

Produktnummer ABIN6258564

Produktdetails anti-USP44 Antikörper

Target: USP44 (Ubiquitin Specific Peptidase 44 (USP44))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser USP44 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Spezifität: USP44 Antibody detects endogenous levels of total USP44.

Homologie: Bovine,Horse,Sheep,Dog

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human USP44, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu USP44

Target: USP44 (Ubiquitin Specific Peptidase 44 (USP44))

Andere Bezeichnung: USP44 (USP44 Produkte)

Synonyme: usp44 antikoerper, USP49 antikoerper, E430004F17Rik antikoerper, zgc:55661 antikoerper, ubiquitin specific peptidase 44 antikoerper, ubiquitin specific peptidase 44 L homeolog antikoerper, ubiquitin specific peptidase 44 S homeolog antikoerper, USP44 antikoerper, usp44.L antikoerper, usp44.S antikoerper, usp44 antikoerper, Usp44 antikoerper

Hintergrund:

Description: Deubiquitinase that plays a key regulatory role in the spindle assembly checkpoint or mitotic checkpoint by preventing premature anaphase onset. Acts by specifically mediating deubiquitination of CDC20, a negative regulator of the anaphase promoting complex/cyclosome (APC/C). Deubiquitination of CDC20 leads to stabilize the MAD2L1-CDC20-APC/C ternary complex (also named mitotic checkpoint complex), thereby preventing premature activation of the APC/C. Promotes association of MAD2L1 with CDC20 and reinforces the spindle assembly checkpoint. Acts as a negative regulator of histone H2B (H2BK120ub1) ubiquitination.

Gene: USP44

Molekulargewicht: 81 kDa

Gen-ID: 84101

UniProt: Q9H0E7

Pathways: M Phase