SMO Antikörper (N-Term)

Produktnummer ABIN6258327

Produktdetails anti-SMO Antikörper

Target: SMO (Smoothened Homolog (Drosophila) (SMO))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SMO Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Spezifität: SMO Antibody detects endogenous levels of total SMO.

Homologie: Pig,Bovine,Horse,Rabbit,Chicken

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human SMO, corresponding to a region within N-terminal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:1000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu SMO

Target: SMO (Smoothened Homolog (Drosophila) (SMO))

Andere Bezeichnung: SMO (SMO Produkte)

Synonyme: FZD11 antikoerper, Gx antikoerper, SMOH antikoerper, Smoh antikoerper, E130215L21Rik antikoerper, bnb antikoerper, smoothened antikoerper, XSmo antikoerper, smoothened, frizzled class receptor antikoerper, smoothened, frizzled class receptor L homeolog antikoerper, SMO antikoerper, Smo antikoerper, smo.L antikoerper, smo antikoerper

Hintergrund:

Description: G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7, GLI2 and GLI3 in the cilia (PubMed:19592253). Interacts with DLG5 at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity).

Gene: SMO

Molekulargewicht: 86 kDa

Gen-ID: 6608

UniProt: Q99835

Pathways: Hedgehog Signalweg