CKLF Antikörper
Kurzübersicht für CKLF Antikörper (ABIN6258091)
Target
Alle CKLF Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Spezifität
- CKLF6 Antibody detects endogenous levels of total CKLF6
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Kreuzreaktivität
- Human, Maus
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Aufreinigung
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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Immunogen
- A synthesized peptide
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Isotyp
- IgG
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anti-Chemokine-Like Factor (CKLF) (AA 1-100) antibody
CKLF Reaktivität: Human, Maus, Ratte WB, ELISA, IF (cc), IF (p), IHC (fro), IHC (p) Wirt: Kaninchen Polyclonal unconjugated
anti-Chemokine-Like Factor (CKLF) (C-Term) antibodyCKLF Reaktivität: Human, Maus, Ratte WB, ELISA, IHC Wirt: Kaninchen Polyclonal unconjugated
anti-Chemokine-Like Factor (CKLF) antibodyCKLF Reaktivität: Human WB, ELISA, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Chemokine-Like Factor (CKLF) (C-Term) antibodyCKLF Reaktivität: Human WB, ELISA Wirt: Kaninchen Polyclonal unconjugated
anti-Chemokine-Like Factor (CKLF) (AA 1-67) antibodyCKLF Reaktivität: Human WB Wirt: Kaninchen Polyclonal unconjugated
anti-Chemokine-Like Factor (CKLF) (N-Term) antibodyCKLF Reaktivität: Human WB Wirt: Kaninchen Polyclonal unconjugated
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Applikationshinweise
- WB 1:500~1:1000, IF/ICC 1:100-1:500
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Konzentration
- 1 mg/mL
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Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- Store at -20 °C.Stable for 12 months from date of receipt
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Haltbarkeit
- 12 months
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- CKLF (Chemokine-Like Factor (CKLF))
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Andere Bezeichnung
- CKLF6
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Hintergrund
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Description: Master regulator of recycling and plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Associates with both constitutive and IFNG-induced PD-L1/CD274 at recycling endosomes, where it protects PD-L1/CD274 from being targeted for lysosomal degradation, likely by preventing its STUB1-mediated ubiquitination. May stabilize PD-L1/CD274 expression on antigen presenting cells and potentiates inhibitory signaling by PDCD1/CD279, its receptor on T-cells, ultimately triggering T-cell anergy.
Gene: CMTM6
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Molekulargewicht
- 25 kDa
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Gen-ID
- 54918
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UniProt
- Q9NX76
Target
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