COPS2 Antikörper (Internal Region)

Produktnummer ABIN6258029

Produktdetails anti-COPS2 Antikörper

Target: COPS2 (COP9 Constitutive Photomorphogenic Homolog Subunit 2 (Arabidopsis) (COPS2))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser COPS2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Spezifität: COPS2 Antibody detects endogenous levels of total COPS2.

Homologie: Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human COPS2, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:1000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu COPS2

Target: COPS2 (COP9 Constitutive Photomorphogenic Homolog Subunit 2 (Arabidopsis) (COPS2))

Andere Bezeichnung: COPS2 (COPS2 Produkte)

Synonyme: COPS2 antikoerper, ALIEN antikoerper, CSN2 antikoerper, SGN2 antikoerper, TRIP15 antikoerper, wu:fc05f05 antikoerper, wu:fc06g10 antikoerper, wu:fc60f04 antikoerper, wu:fl94f12 antikoerper, zgc:86624 antikoerper, csn2 antikoerper, Tb03.48O8.600 antikoerper, Trip15 antikoerper, AI315723 antikoerper, C85265 antikoerper, Csn2 antikoerper, Sgn2 antikoerper, alien-like antikoerper, ATCSN2 antikoerper, CONSTITUTIVE PHOTOMORPHOGENIC 12 antikoerper, COP12 antikoerper, FUSCA 12 antikoerper, T20P8.4 antikoerper, T20P8_4 antikoerper, COP9 signalosome subunit 2 antikoerper, COP9 signalosome subunit 2 L homeolog antikoerper, COP9 signalosome complex subunit 2 antikoerper, COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis) antikoerper, proteasome family protein antikoerper, COPS2 antikoerper, cops2 antikoerper, cops2.L antikoerper, Tb927.3.2320 antikoerper, AOR_1_576084 antikoerper, PTRG_07106 antikoerper, LOC100283498 antikoerper, Cops2 antikoerper, csn-2 antikoerper, FUS12 antikoerper

Hintergrund:

Description: Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1.

Gene: COPS2

Molekulargewicht: 55 kDa

Gen-ID: 9318

UniProt: P61201

Pathways: Zellzyklus