TEAD3 Antikörper (Internal Region)

Produktnummer ABIN6257529

Der Kaninchen-Polyklonal Anti-TEAD3-Antikörper wurde für ELISA, WB, IF und ICC validiert. Er ist geeignet zum Nachweis von TEAD3 in Proben aus Human und Maus. }

Kurzübersicht für TEAD3 Antikörper (Internal Region) (ABIN6257529)

Target: TEAD3 (TEA Domain Family Member 3 (TEAD3))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TEAD3 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)

Produktdetails anti-TEAD3 Antikörper

Bindungsspezifität: Internal Region

Spezifität: TEAD3 Antibody detects endogenous levels of total TEAD3.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human TEAD3, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu TEAD3

Target: TEAD3 (TEA Domain Family Member 3 (TEAD3))

Andere Bezeichnung: TEAD3

Hintergrund:

Description: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer.

Gene: TEAD3

Molekulargewicht: 49 kDa

Gen-ID: 7005

UniProt: Q99594

Pathways: Regulation of Lipid Metabolism by PPARalpha