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RPS3 Antikörper (Internal Region)

Der Kaninchen Polyklonal Anti-RPS3-Antikörper wurde für WB, IHC, ELISA, IF und ICC validiert. Er ist geeignet, RPS3 in Proben von Human, Maus und Ratte zu detektieren.
Produktnummer ABIN6257472

Kurzübersicht für RPS3 Antikörper (Internal Region) (ABIN6257472)

Target

Alle RPS3 Antikörper anzeigen
RPS3 (Ribosomal Protein S3 (RPS3))

Reaktivität

  • 61
  • 48
  • 26
  • 16
  • 5
  • 5
  • 4
  • 4
  • 4
  • 3
  • 3
  • 2
  • 2
  • 1
Human, Maus, Ratte

Wirt

  • 57
  • 4
Kaninchen

Klonalität

  • 48
  • 13
Polyklonal

Konjugat

  • 27
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser RPS3 Antikörper ist unkonjugiert

Applikation

  • 41
  • 16
  • 13
  • 13
  • 13
  • 7
  • 7
  • 5
  • 4
  • 3
  • 2
  • 2
Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
  • Bindungsspezifität

    • 15
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region

    Spezifität

    RPS3 Antibody detects endogenous levels of total RPS3.

    Homologie

    Pig,Zebrafish,Bovine,Sheep,Rabbit,Dog,Chicken,Xenopus

    Aufreinigung

    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).

    Immunogen

    A synthesized peptide derived from human RPS3, corresponding to a region within the internal amino acids.

    Isotyp

    IgG
  • Applikationshinweise

    WB 1:500-1:1000, IHC: 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 mg/mL

    Buffer

    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20 °C. Stable for 12 months from date of receipt.

    Haltbarkeit

    12 months
  • Target

    RPS3 (Ribosomal Protein S3 (RPS3))

    Andere Bezeichnung

    RPS3

    Hintergrund

    Description: Involved in translation as a component of the 40S small ribosomal subunit (PubMed:8706699). Has endonuclease activity and plays a role in repair of damaged DNA (PubMed:7775413). Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA (PubMed:15707971). Displays high binding affinity for 7,8-dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS) (PubMed:14706345). Has also been shown to bind with similar affinity to intact and damaged DNA (PubMed:18610840). Stimulates the N-glycosylase activity of the base excision protein OGG1 (PubMed:15518571). Enhances the uracil excision activity of UNG1 (PubMed:18973764). Also stimulates the cleavage of the phosphodiester backbone by APEX1 (PubMed:18973764). When located in the mitochondrion, reduces cellular ROS levels and mitochondrial DNA damage (PubMed:23911537). Has also been shown to negatively regulate DNA repair in cells exposed to hydrogen peroxide (PubMed:17049931). Plays a role in regulating transcription as part of the NF-kappa-B p65-p50 complex where it binds to the RELA/p65 subunit, enhances binding of the complex to DNA and promotes transcription of target genes (PubMed:18045535). Represses its own translation by binding to its cognate mRNA (PubMed:20217897). Binds to and protects TP53/p53 from MDM2-mediated ubiquitination (PubMed:19656744). Involved in spindle formation and chromosome movement during mitosis by regulating microtubule polymerization (PubMed:23131551). Involved in induction of apoptosis through its role in activation of CASP8 (PubMed:14988002). Induces neuronal apoptosis by interacting with the E2F1 transcription factor and acting synergistically with it to up-regulate pro-apoptotic proteins BCL2L11/BIM and HRK/Dp5 (PubMed:20605787). Interacts with TRADD following exposure to UV radiation and induces apoptosis by caspase-dependent JNK activation (PubMed:22510408).

    Gene: RPS3

    Molekulargewicht

    30 kDa

    Gen-ID

    6188

    UniProt

    P23396

    Pathways

    Positive Regulation of Endopeptidase Activity
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