ZBTB33 Antikörper (N-Term)
Kurzübersicht für ZBTB33 Antikörper (N-Term) (ABIN6257304)
Target
Alle ZBTB33 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
-
-
Bindungsspezifität
- N-Term
-
Spezifität
- ZBTB33 Antibody detects endogenous levels of total ZBTB33.
-
Homologie
- Bovine,Horse,Sheep
-
Aufreinigung
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
-
Immunogen
- A synthesized peptide derived from human ZBTB33, corresponding to a region within N-terminal amino acids.
-
Isotyp
- IgG
-
-
-
-
Applikationshinweise
- WB 1:500-1:2000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
-
Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
-
-
Format
- Liquid
-
Konzentration
- 1 mg/mL
-
Buffer
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
-
Konservierungsmittel
- Sodium azide
-
Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Lagerung
- -20 °C
-
Haltbarkeit
- 12 months
-
-
- ZBTB33 (Zinc Finger and BTB Domain Containing 33 (ZBTB33))
-
Andere Bezeichnung
- ZBTB33
-
Hintergrund
-
Description: Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS). Recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. May contribute to the repression of target genes of the Wnt signaling pathway. May also activate transcription of a subset of target genes by the recruitment of CTNND2. Represses expression of MMP7 in conjunction with transcriptional corepressors CBFA2T3, CBFA2T2 and RUNX1T1 (PubMed:23251453).
Gene: ZBTB33
-
Molekulargewicht
- 95 kDa
-
Gen-ID
- 10009
-
UniProt
- Q86T24
Target
-