Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

C1QBP Antikörper (Internal Region)

Dieses Anti-C1QBP-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von C1QBP in WB, IHC, ICC, IF und ELISA. Geeignet für Human, Maus und Ratte.
Produktnummer ABIN6256975

Kurzübersicht für C1QBP Antikörper (Internal Region) (ABIN6256975)

Target

Alle C1QBP Antikörper anzeigen
C1QBP (Complement Component 1, Q Subcomponent Binding Protein (C1QBP))

Reaktivität

  • 93
  • 45
  • 32
  • 3
  • 3
  • 2
  • 1
  • 1
  • 1
Human, Maus, Ratte

Wirt

  • 100
  • 28
  • 1
Kaninchen

Klonalität

  • 89
  • 40
Polyklonal

Konjugat

  • 80
  • 14
  • 14
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser C1QBP Antikörper ist unkonjugiert

Applikation

  • 105
  • 54
  • 38
  • 31
  • 25
  • 19
  • 17
  • 13
  • 13
  • 7
  • 7
  • 6
  • 4
  • 4
  • 3
  • 2
  • 2
Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF), ELISA
  • Bindungsspezifität

    • 19
    • 15
    • 12
    • 6
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region

    Spezifität

    C1QBP Antibody detects endogenous levels of total C1QBP.

    Homologie

    Pig,Zebrafish,Bovine,Horse,Sheep,Dog,Xenopus

    Aufreinigung

    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).

    Immunogen

    A synthesized peptide derived from human C1QBP, corresponding to a region within the internal amino acids.

    Isotyp

    IgG
  • Applikationshinweise

    WB 1:500-1:1000, IHC: 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 mg/mL

    Buffer

    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20 °C. Stable for 12 months from date of receipt.

    Haltbarkeit

    12 months
  • Target

    C1QBP (Complement Component 1, Q Subcomponent Binding Protein (C1QBP))

    Andere Bezeichnung

    C1QBP

    Hintergrund

    Description: Is believed to be a multifunctional and multicompartmental protein involved in inflammation and infection processes, ribosome biogenesis, protein synthesis in mitochondria, regulation of apoptosis, transcriptional regulation and pre-mRNA splicing. At the cell surface is thought to act as an endothelial receptor for plasma proteins of the complement and kallikrein-kinin cascades. Putative receptor for C1q, specifically binds to the globular "heads" of C1q thus inhibiting C1, may perform the receptor function through a complex with C1qR/CD93. In complex with cytokeratin-1/KRT1 is a high affinity receptor for kininogen-1/HMWK. Can also bind other plasma proteins, such as coagulation factor XII leading to its autoactivation. May function to bind initially fluid kininogen-1 to the cell membrane. The secreted form may enhance both extrinsic and intrinsic coagulation pathways. It is postulated that the cell surface form requires docking with transmembrane proteins for downstream signaling which might be specific for a cell-type or response. By acting as C1q receptor is involved in chemotaxis of immature dendritic cells and neutrophils and is proposed to signal through CD209/DC-SIGN on immature dendritic cells, through integrin alpha-4/beta-1 during trophoblast invasion of the decidua, and through integrin beta-1 during endothelial cell adhesion and spreading. Signaling involved in inhibition of innate immune response is implicating the PI3K-AKT/PKB pathway. Required for protein synthesis in mitochondria (PubMed:28942965). In mitochondrial translation may be involved in formation of functional 55S mitoribosomes, the function seems to involve its RNA-binding activity. May be involved in the nucleolar ribosome maturation process, the function may involve the exchange of FBL for RRP1 in the association with pre-ribosome particles. Involved in regulation of RNA splicing by inhibiting the RNA-binding capacity of SRSF1 and its phosphorylation. Is required for the nuclear translocation of splicing factor U2AF1L4. Involved in regulation of CDKN2A- and HRK-mediated apoptosis. Stabilizes mitochondrial CDKN2A isoform smARF. May be involved in regulation of FOXC1 transcriptional activity and NFY/CCAAT-binding factor complex-mediated transcription. May play a role in antibacterial defense as it can bind to cell surface hyaluronan and inhibit Streptococcus pneumoniae hyaluronate lyase. May be involved in modulation of the immune response, ligation by HCV core protein is resulting in suppression of interleukin-12 production in monocyte-derived dendritic cells. Involved in regulation of antiviral response by inhibiting DDX58- and IFIH1-mediated signaling pathways probably involving its association with MAVS after viral infection.

    Gene: C1QBP

    Molekulargewicht

    32 kDa

    Gen-ID

    708

    UniProt

    Q07021

    Pathways

    Ribonucleoprotein Complex Subunit Organization, Ribosome Assembly
Sie sind hier:
Chat with us!