Cadherin 5 Antikörper (pTyr731)

Produktnummer ABIN6256011

Der Kaninchen Polyklonal Anti-Cadherin 5-Antikörper wurde für WB, IHC, ELISA, ICC und IF validiert. Er ist geeignet, Cadherin 5 in Proben von Human und Maus zu detektieren.

Kurzübersicht für Cadherin 5 Antikörper (pTyr731) (ABIN6256011)

Target: Cadherin 5 (CDH5)

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Cadherin 5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Produktdetails anti-Cadherin 5 Antikörper

Bindungsspezifität: pTyr731

Spezifität: Phospho-VE-Cadherin (Tyr731) Antibody detects endogenous levels of VE-Cadherin only when phosphorylated at Tyrosine 731.

Homologie: Pig,Zebrafish,Bovine,Horse,Sheep,Dog,Chicken

Aufreinigung: The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.

Immunogen: A synthesized peptide derived from human VE-Cadherin around the phosphorylation site of Tyr731.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu Cadherin 5

Target: Cadherin 5 (CDH5)

Andere Bezeichnung: CDH5

Hintergrund:

Description: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells, cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton. Acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen. These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for activation of PRKCZ and for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction.

Gene: CDH5

Molekulargewicht: 130kDa

Gen-ID: 1003

UniProt: P33151

Pathways: Cell-Cell Junction Organization, Signaling Events mediated by VEGFR1 and VEGFR2