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FOXO3 Antikörper (pSer253)

Name: FOXO3 Antikörper (pSer253)
SKU: ABIN6255131
Price: 720 EUR
Availability: InStock

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch FOXO3 in WB, IHC, ELISA, IF und ICC. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte und wurde in 1 Publikation erwähnt.

Western blot analysis of FKHRL1 phosphorylation expression in serum treated NIH-3T3 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. (FOXO3 Antikörper (pSer253))

ABIN6267237 at 1/100 staining mouse brain tissue sections by IHC-P. (FOXO3 Antikörper (pSer253))

IHC

ABIN6267237 at 1/100 staining human appendiceal tissue sections by IHC-P. (FOXO3 Antikörper (pSer253))

IHC

ABIN6267237 at 1/100 staining mouse kidney tissue sections by IHC-P. (FOXO3 Antikörper (pSer253))

12 Abbildungen

(1 reference)

Produktnummer ABIN6255131

Kurzübersicht für FOXO3 Antikörper (pSer253) (ABIN6255131)

Target

Alle FOXO3 Antikörper anzeigen

FOXO3 (Forkhead Box O3 (FOXO3))

Reaktivität

Human, Maus, Ratte

Wirt

Kaninchen

Klonalität

Polyklonal

Konjugat

Dieser FOXO3 Antikörper ist unkonjugiert

Applikation

Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Discover our top product FOXO3 Primärantikörper

Bindungsspezifität
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pSer253

Spezifität

Phospho-FOXO3A (Ser253) Antibody detects endogenous levels of FOXO3A only when phosphorylated at Serine 253.

Homologie

Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Aufreinigung

The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.

Immunogen

A synthesized peptide derived from human FOXO3A around the phosphorylation site of Ser253.

Isotyp

IgG
anti-Forkhead Box O3 (FOXO3) (AA 394-672) antibody
FOXO3 Reaktivität: Maus WB, IHC, IF Wirt: Kaninchen Polyclonal unconjugated

anti-Forkhead Box O3 (FOXO3) (C-Term) antibody
Verified FOXO3 Reaktivität: Human WB, IHC, ELISA Wirt: Ziege Polyclonal unconjugated

anti-Forkhead Box O3 (FOXO3) (pSer318), (pSer321) antibody
FOXO3 Reaktivität: Human, Ratte WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) Wirt: Kaninchen Polyclonal unconjugated

anti-Forkhead Box O3 (FOXO3) (C-Term) antibody
KO Validated FOXO3 Reaktivität: Human WB, IF, IHC (p), IP, ICC Wirt: Kaninchen Polyclonal unconjugated

anti-Forkhead Box O3 (FOXO3) (N-Term) antibody
FOXO3 Reaktivität: Human, Maus, Ratte, Hund, Rind (Kuh), Schwein, Schaf, Kaninchen, Meerschweinchen, Zebrafisch (Danio rerio) WB Wirt: Kaninchen Polyclonal unconjugated

anti-Forkhead Box O3 (FOXO3) antibody
FOXO3 Reaktivität: Human WB, IHC, ELISA, IF Wirt: Kaninchen Monoclonal 1E2 unconjugated Recombinant Antibody

anti-Forkhead Box O3 (FOXO3) (N-Term) antibody
FOXO3 Reaktivität: Human, Maus, Ratte WB, IHC, ELISA, IHC (p), ICC Wirt: Kaninchen Polyclonal unconjugated

anti-Forkhead Box O3 (FOXO3) (pSer425) antibody
FOXO3 Reaktivität: Human WB, IHC Wirt: Kaninchen Polyclonal unconjugated

anti-Forkhead Box O3 (FOXO3) (AA 361-460) antibody
FOXO3 Reaktivität: Human ELISA, IF, IHC (p) Wirt: Maus Monoclonal 1E11 unconjugated

anti-Forkhead Box O3 (FOXO3) (AA 361-460) antibody
FOXO3 Reaktivität: Human WB, ELISA, IF, IHC (p) Wirt: Maus Monoclonal 1F6 unconjugated

Applikationshinweise

WB 1:500-1:2000, IHC 1:50-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Beschränkungen

Nur für Forschungszwecke einsetzbar
Format

Liquid

Konzentration

1 mg/mL

Buffer

Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel

Sodium azide

Vorsichtsmaßnahmen

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung

-20 °C

Informationen zur Lagerung

Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit

12 months
Yang, Lv, Chen, Wang, Liu, Shi, Liu, Wang: "The effect of vitamin D on sarcopenia depends on the level of physical activity in older adults." in: Journal of cachexia, sarcopenia and muscle, Vol. 11, Issue 3, pp. 678-689, (2021) (PubMed).
Target

FOXO3 (Forkhead Box O3 (FOXO3))

Andere Bezeichnung

FOXO3

Hintergrund

Description: Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress (PubMed:10102273, PubMed:16751106). Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3' (PubMed:21329882). Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation (PubMed:21329882). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription (PubMed:23283301).
Gene: FOXO3

Molekulargewicht

97kDa

Gen-ID

2309

UniProt

O43524

Pathways

Zellzyklus, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Carbohydrate Homeostasis